Shopping Cart
Remove All
Your shopping cart is currently empty
Posovolone
Copy Product Info
🥰Excellent
Catalog No. T40205Cas No. 256955-84-7
Alias Co 134444
Posovolone (Co 134444), an orally active neuroactive steroid with sedative-hypnotic properties, exhibits anticonvulsant and anxiolytic-like activities, alongside ataxic effects.
Posovolone
Copy Product Info🥰Excellent
Catalog No. T40205Alias Co 134444Cas No. 256955-84-7
Posovolone (Co 134444), an orally active neuroactive steroid with sedative-hypnotic properties, exhibits anticonvulsant and anxiolytic-like activities, alongside ataxic effects.
Product information is being updated, if you want to purchase, please click the bulk custom button.
Add to Quotation
Resource Download
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Posovolone (Co 134444), an orally active neuroactive steroid with sedative-hypnotic properties, exhibits anticonvulsant and anxiolytic-like activities, alongside ataxic effects. |
| In vitro | In mice, the administration of Co 134444, ranging from 0.5-10 mg/kg intraperitoneally (IP, 15 min) and 1-60 mg/kg orally (PO; 30 min), is effective against pentylenetetrazol (PTZ)-induced seizures, achieving a median effective dose (ED50) of 3.3 mg/kg for IP and 9.8 mg/kg for oral administration. Similarly, Co 134444 demonstrates efficacy in protecting against maximal electroshock (MES)-induced seizures, with an ED50 of 4.8 mg/kg when administered IP and 20.6 mg/kg PO. In rats, oral administration of Co 134444 (10-40 mg/kg; PO; 30 min) effectively counters both PTZ and MES-induced seizures, with an ED50 of 23.6 mg/kg and 25.3 mg/kg, respectively. |
| Synonyms | Co 134444 |
| Molecular Weight | 428.617 |
| Formula | C26H40N2O3 |
| Cas No. | 256955-84-7 |
| Smiles | [H][C@@]1(CC[C@@]2([H])[C@]3([H])CC[C@@]4([H])C[C@@](O)(COC)CC[C@]4(C)[C@@]3([H])CC[C@]12C)C(=O)Cn1ccnc1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy Posovolone | purchase Posovolone | Posovolone cost | order Posovolone | Posovolone chemical structure | Posovolone in vitro | Posovolone formula | Posovolone molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.