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Posovolone

Catalog No. T40205 CAS 256955-84-7

Synonyms: Co 134444

Posovolone (Co 134444), an orally active neuroactive steroid with sedative-hypnotic properties, exhibits anticonvulsant and anxiolytic-like activities, alongside ataxic effects.

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Posovolone, CAS 256955-84-7

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Posovolone (Co 134444), an orally active neuroactive steroid with sedative-hypnotic properties, exhibits anticonvulsant and anxiolytic-like activities, alongside ataxic effects.

In vitro

In mice, the administration of Co 134444, ranging from 0.5-10 mg/kg intraperitoneally (IP, 15 min) and 1-60 mg/kg orally (PO; 30 min), is effective against pentylenetetrazol (PTZ)-induced seizures, achieving a median effective dose (ED50) of 3.3 mg/kg for IP and 9.8 mg/kg for oral administration. Similarly, Co 134444 demonstrates efficacy in protecting against maximal electroshock (MES)-induced seizures, with an ED50 of 4.8 mg/kg when administered IP and 20.6 mg/kg PO. In rats, oral administration of Co 134444 (10-40 mg/kg; PO; 30 min) effectively counters both PTZ and MES-induced seizures, with an ED50 of 23.6 mg/kg and 25.3 mg/kg, respectively.

Synonyms	Co 134444
Molecular Weight	428.617
Formula	C26H40N2O3
CAS No.	256955-84-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Vanover KE, et al. Behavioral characterization of Co 134444 (3alpha-hydroxy-21-(1'-imidazolyl)-3beta-methoxymethyl-5alpha- pregnan-20-one), a novel sedative-hypnotic neuroactive steroid. Psychopharmacology (Berl). 2001;155(3):285-291.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Posovolone 256955-84-7 Co 134444 inhibitor inhibit

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