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Anti-XRN2 Antibody (1B629)

😃Good
Catalog No. TMAC-04303

Anti-XRN2 Antibody (1B629) is a Mouse antibody targeting XRN2. Anti-XRN2 Antibody (1B629) can be used in WB,IHC.

Anti-XRN2 Antibody (1B629)

Anti-XRN2 Antibody (1B629)

😃Good
Catalog No. TMAC-04303
Anti-XRN2 Antibody (1B629) is a Mouse antibody targeting XRN2. Anti-XRN2 Antibody (1B629) can be used in WB,IHC.
Pack SizePriceAvailabilityQuantity
50 μL$2977-10 days
100 μL$4287-10 days
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Product Introduction

Bioactivity
Description
Anti-XRN2 Antibody (1B629) is a Mouse antibody targeting XRN2. Anti-XRN2 Antibody (1B629) can be used in WB,IHC.
Reactivity
Human
Application
Recommended Dose
WB: 1:500-2000; IHC: 1:200-500
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionHybridoma Monoclonal Antibody
PurificationProA affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research BackgroundDegradation of mRNA is a critical aspect of gene expression that occurs via the exoribonuclease. Exoribonuclease 2 (XRN2) is the human homologue of the Saccharomyces cerevisiae RAT1, which functions as a nuclear 5' to 3' exoribonuclease and is essential for mRNA turnover and cell viability. XRN2 also processes rRNAs and small nucleolar RNAs (snoRNAs) in the nucleus. XRN2 moves along with RNA polymerase II and gains access to the nascent RNA transcript after the endonucleolytic cleavage at the poly(A) site or at a second cotranscriptional cleavage site (CoTC). CoTC is an autocatalytic RNA structure that undergoes rapid self-cleavage and acts as a precursor to termination by presenting a free RNA 5' end to be recognized by XRN2. XRN2 then travels in a 5'-3' direction like a guided torpedo and facilitates the dissociation of the RNA polymerase elongation complex.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Protein
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 109 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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