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Pim1/AKK1-IN-1

Name: Pim1/AKK1-IN-1
Brand: TargetMol
SKU: T5093
Price: 82 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T5093Cas No. 1093222-27-5

Alias MDK-2275, LKB1/AAK1 dual inhibitor

Pim1/AKK1-IN-1 (LKB1/AAK1 dual inhibitor) is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK.

Pim1/AKK1-IN-1

🥰Excellent

Purity: 98.69%

Catalog No. T5093Alias MDK-2275, LKB1/AAK1 dual inhibitorCas No. 1093222-27-5

Pim1/AKK1-IN-1 (LKB1/AAK1 dual inhibitor) is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK.

Pack Size	Price	Availability
1 mg	$82	In Stock
2 mg	$133	In Stock
5 mg	$193	In Stock
10 mg	$292	In Stock
25 mg	$515	In Stock
50 mg	$747	In Stock
100 mg	$1,050	In Stock
1 mL x 10 mM (in DMSO)	$213	In Stock

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Purity:98.69%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Pim1/AKK1-IN-1 (LKB1/AAK1 dual inhibitor) is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK.
Targets&IC50	Pim1:35 nM (Kd), AKK1:53 nM (Kd), MST2:75 nM (Kd), LKB1:380 nM (Kd)
Synonyms	MDK-2275, LKB1/AAK1 dual inhibitor

Chemical Properties

Molecular Weight	339.35
Formula	C₂₀H₁₃N₅O
Cas No.	1093222-27-5
Smiles	O=C(Nc1c[nH]c2ncc(cc12)-c1ccc(cc1)C#N)c1cccnc1
Relative Density.	1.42
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 15 mg/mL (44.2 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.89 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9468 mL	14.7341 mL	29.4681 mL	147.3405 mL
5 mM	0.5894 mL	2.9468 mL	5.8936 mL	29.4681 mL
10 mM	0.2947 mL	1.4734 mL	2.9468 mL	14.7341 mL
20 mM	0.1473 mL	0.7367 mL	1.4734 mL	7.3670 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc