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CAM 833

Name: CAM 833
Brand: TargetMol
SKU: T41211
Price: 293 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T41211Cas No. 2758364-02-0

Alias CAM833

CAM 833 is an effective orthosteric inhibitor of the BRCA2-RAD51 interaction, inhibiting RAD51 aggregation, enhancing DNA damage-induced apoptosis, increasing 4N cell cycle arrest, and disrupting homologous DNA repair (HDR), and can be used for cancer therapy.

CAM 833

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Purity: 99.83%

Catalog No. T41211Alias CAM833Cas No. 2758364-02-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$293	-	In Stock
5 mg	$722	-	In Stock
10 mg	$987	-	In Stock
25 mg	$1,520	-	In Stock
50 mg	$1,980	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.83%

Appearance:Solid

Color:White

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COA HNMR

Product Introduction

Bioactivity

Description	CAM 833 is an effective orthosteric inhibitor of the BRCA2-RAD51 interaction, inhibiting RAD51 aggregation, enhancing DNA damage-induced apoptosis, increasing 4N cell cycle arrest, and disrupting homologous DNA repair (HDR), and can be used for cancer therapy.
In vitro	Methods: HCT116 cells were treated with CAM 833 (20 μM, 0-72 hours) to study its effect on the cell cycle of HCT116 cells. Results: In the control group, the percentage of cells in the G1 fraction of apoptosis remained below 5%. In the compound-treated cells, the percentage of cells in the G1 fraction gradually increased, reaching a peak of 15% at 48 hours. [1]
Synonyms	CAM833

Chemical Properties

Molecular Weight	528.96
Formula	C₂₆H₂₆ClFN₄O₅
Cas No.	2758364-02-0
Smiles	C(N[C@@H](C)C1=C(Cl)C=C(OC)C=C1)(=O)[C@H]2N(C(CNC(=O)C3=NC4=C(C=C3)C=C(F)C=C4)=O)C[C@H](O)C2

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 105 mg/mL (198.5 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8905 mL	9.4525 mL	18.9050 mL	94.5251 mL
5 mM	0.3781 mL	1.8905 mL	3.7810 mL	18.9050 mL
10 mM	0.1891 mL	0.9453 mL	1.8905 mL	9.4525 mL
20 mM	0.0945 mL	0.4726 mL	0.9453 mL	4.7263 mL
50 mM	0.0378 mL	0.1891 mL	0.3781 mL	1.8905 mL
100 mM	0.0189 mL	0.0945 mL	0.1891 mL	0.9453 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc