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CAM 833

Name: CAM 833
Brand: TargetMol
SKU: T41211
Price: 293 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T41211Cas No. 2758364-02-0

Alias CAM833

CAM 833 is an effective orthosteric inhibitor of the BRCA2-RAD51 interaction, inhibiting RAD51 aggregation, enhancing DNA damage-induced apoptosis, increasing 4N cell cycle arrest, and disrupting homologous DNA repair (HDR), and can be used for cancer therapy.

CAM 833

🥰Excellent

Purity: 99.83%

Catalog No. T41211Alias CAM833Cas No. 2758364-02-0

Pack Size	Price	Availability
1 mg	$293	In Stock
5 mg	$722	In Stock
10 mg	$987	In Stock
25 mg	$1,520	In Stock
50 mg	$1,980	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.83%

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COA HNMR

Product Introduction

Bioactivity

Description	CAM 833 is an effective orthosteric inhibitor of the BRCA2-RAD51 interaction, inhibiting RAD51 aggregation, enhancing DNA damage-induced apoptosis, increasing 4N cell cycle arrest, and disrupting homologous DNA repair (HDR), and can be used for cancer therapy.
In vitro	Methods: HCT116 cells were treated with CAM 833 (20 μM, 0-72 hours) to study its effect on the cell cycle of HCT116 cells. Results: In the control group, the percentage of cells in the G1 fraction of apoptosis remained below 5%. In the compound-treated cells, the percentage of cells in the G1 fraction gradually increased, reaching a peak of 15% at 48 hours. [1]
Synonyms	CAM833

Chemical Properties

Molecular Weight	528.96
Formula	C₂₆H₂₆ClFN₄O₅
Cas No.	2758364-02-0
Smiles	C(N[C@@H](C)C1=C(Cl)C=C(OC)C=C1)(=O)[C@H]2N(C(CNC(=O)C3=NC4=C(C=C3)C=C(F)C=C4)=O)C[C@H](O)C2

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 105 mg/mL (198.5 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8905 mL	9.4525 mL	18.9050 mL	94.5251 mL
5 mM	0.3781 mL	1.8905 mL	3.7810 mL	18.9050 mL
10 mM	0.1891 mL	0.9453 mL	1.8905 mL	9.4525 mL
20 mM	0.0945 mL	0.4726 mL	0.9453 mL	4.7263 mL
50 mM	0.0378 mL	0.1891 mL	0.3781 mL	1.8905 mL
100 mM	0.0189 mL	0.0945 mL	0.1891 mL	0.9453 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc