Anti-JMJD2A Antibody (6H812) is a Rabbit antibody targeting JMJD2A. Anti-JMJD2A Antibody (6H812) can be used in IF, IHC-Fr, IHC-P, IP, WB.

IgG

6H812

Human (predicted:Mouse,Rat)

25 ug total protein per lane of various lysates (see on figure) probed with JMJD2A monoclonal antibody, unconjugated (TMAB-07871) at 1: 1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r. T. for 60 min.

IF=1:100-200; IHC-Fr=1:100-200; IHC-P=1:100-200; IP=1:20-50; WB=1:500-2000

Monoclonal

A synthesized peptide: human KDM4A

Human

KDM4A

Lysine-specific demethylase 4A

Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.