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PK 11195

Name: PK 11195
Brand: TargetMol
SKU: T16546
Price: 69 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16546Cas No. 85532-75-8

Alias RP 52028

PK 11195 (RP 52028) is a TSPO ligand for neuroimaging that exhibits significant protection against CoCl2-induced alterations and can be used to study leishmaniasis.

PK 11195

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Purity: 99.05%

Catalog No. T16546Alias RP 52028Cas No. 85532-75-8

PK 11195 (RP 52028) is a TSPO ligand for neuroimaging that exhibits significant protection against CoCl2-induced alterations and can be used to study leishmaniasis.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	-
5 mg	Preferential	7-10 days	7-10 days
1 mL x 10 mM (in DMSO)	$69	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.05%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	PK 11195 (RP 52028) is a TSPO ligand for neuroimaging that exhibits significant protection against CoCl2-induced alterations and can be used to study leishmaniasis.
Targets&IC50	L. braziliensis:3.5 μM, L. amazonensis:14.2 μM, L. major:8.2 μM
In vitro	PK11195 (0.2-400 μM; 48h) exhibits in vitro antileishmanial activity against Lactobacillus amazonicus.
Synonyms	RP 52028

Chemical Properties

Molecular Weight	352.86
Formula	C₂₁H₂₁ClN₂O
Cas No.	85532-75-8
Smiles	CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl
Relative Density.	1.179g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 15 mg/mL (42.51 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.67 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8340 mL	14.1699 mL	28.3399 mL	141.6993 mL
5 mM	0.5668 mL	2.8340 mL	5.6680 mL	28.3399 mL
10 mM	0.2834 mL	1.4170 mL	2.8340 mL	14.1699 mL
20 mM	0.1417 mL	0.7085 mL	1.4170 mL	7.0850 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc