Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Compound 5k (Antiproliferative Agent-18) is an antiproliferative agent that exhibits moderate antibacterial and antifungal activities [1].
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Description | Compound 5k (Antiproliferative Agent-18) is an antiproliferative agent that exhibits moderate antibacterial and antifungal activities [1]. |
In vitro | Antiproliferative agent-18 (Compound 5k) demonstrated moderate antibacterial activity (inhibition zones of 14-17 mm) at 200 µg/8 mm disc over 24 h against bacteria and 48 h for fungi, with similar moderate activity against the yeast-like pathogen Candida albicans (inhibition zone of 17 mm) [1]. Additionally, this agent exhibited antiproliferative effects on various human cancer cell lines including prostate (PC-3), colorectal (HCT-116), hepatocellular (HepG-2), epidermoid cervical (HeLa), and breast (MCF-7) at concentrations of 0.1-100 μM over 48 hours [1]. Antiproliferative agent-18 also occupied the active site of the SIRT1 enzyme, taking the place of the NAD cofactor and the histone deacetylase inhibitor EX527 [1]. |
Molecular Weight | 434.57 |
Formula | C26H27FN2OS |
CAS No. | 2882206-14-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Antiproliferative agent-18 2882206-14-4 inhibitor inhibit