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Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody 3
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Catalog No. TMAB-11105
Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody 3 is a Rabbit antibody targeting Phospho-PAK2 (Ser141). Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody 3 can be used in IHC-P,IHC-Fr,IF.
Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody 3
Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody 3
😃Good
Catalog No. TMAB-11105
Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody 3 is a Rabbit antibody targeting Phospho-PAK2 (Ser141). Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody 3 can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $371 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody 3 is a Rabbit antibody targeting Phospho-PAK2 (Ser141). Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody 3 can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Mouse (predicted:Human,Rat,Dog,Cow,Horse,Rabbit) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm and Nucleus. Cytoplasm > perinuclear region. Membrane. Interaction with ARHGAP10 probably changes PAK-2p34 location to cytoplasmic perinuclear region. Myristoylation changes PAK-2p34 location to the membrane. |
| Tissue Specificity | Ubiquitously expressed. Higher levels seen in skeletal muscle, ovary, thymus and spleen. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008] |
| Immunogen | KLH conjugated Synthesised phosphopeptide: human PAK2 around the phosphorylation site of Ser141 |
| Antigen Species | Human |
| Gene Name | PAK2 |
| Gene ID | |
| Protein Name | Serine/threonine-protein kinase PAK 2 |
| Uniprot ID | |
| Function | The activated kinase acts on a variety of targets. Phosphorylates ribosomal protein S6, histone H4 and myelin basic protein. Full length PAK 2 stimulates cell survival and cell growth. The process is, at least in part, mediated by phosphorylation and inhibition of pro-apoptotic BAD. Caspase-activated PAK-2p34 is involved in cell death response, probably involving the JNK signaling pathway. Cleaved PAK-2p34 seems to have a higher activity than the CDC42-activated form. |
| Molecular Weight | Theoretical: 23/35/58 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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