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Anti-OSTM1 Antibody (2C40)
😃Good
Catalog No. TMAY-01323
Alias osteopetrosis associated transmembrane protein 1, HSPC019, gl, 1200002H13Rik
Anti-OSTM1 Antibody (2C40) is a Rabbit antibody targeting OSTM1. Anti-OSTM1 Antibody (2C40) can be used in ELISA.
Anti-OSTM1 Antibody (2C40)
Anti-OSTM1 Antibody (2C40)
😃Good
Catalog No. TMAY-01323Alias osteopetrosis associated transmembrane protein 1, HSPC019, gl, 1200002H13Rik
Anti-OSTM1 Antibody (2C40) is a Rabbit antibody targeting OSTM1. Anti-OSTM1 Antibody (2C40) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $270 | 7-10 days |
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Chemical Properties
| Description | Anti-OSTM1 Antibody (2C40) is a Rabbit antibody targeting OSTM1. Anti-OSTM1 Antibody (2C40) can be used in ELISA. |
| Alias | osteopetrosis associated transmembrane protein 1, HSPC019, gl, 1200002H13Rik |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 2C40 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human OSTM1 extracellular domain (rh OSTM1; TMPY-01194; NP_054747.2; Met 1-Pro 284). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Osteopetrosis-associated transmembrane protein 1 (OSTM1) is a Single-pass type I membrane protein. It is expressed in many hematopoietic cells of the myeloid and lymphoid B- and T-lineages. The analysis of OSTM1 association with CLCN7 demonstrated that OSTM1 requires CLCN7 to localize to lysosomes, whereas the formation of a CLCN7-OSTM1 complex is required to stabilize CLCN7. OSTM1 plays a major role in myelopoiesis and lymphopoiesis and provided evidence of a crosstalk mechanism between hematopoietic cells for osteoclast activation. Thus, OSTM1 has an important role in osteoclast function and activation. The loss of function of OSTM1 results in deregulation of multiple hematopoietic lineages in addition to osteoclast lineage, OSTM1-defect patients display the most severe recessive osteopetrosis phenotype and die at early ages. Furthermore, it is suggested that OSTM1 has a primary role in neural development not related to lysosomal dysfunction. The canonical Wnt/beta-catenin signaling pathway may be a molecular basis for OSTM1 mutations and severe autosomal recessive osteopetrosis (ARO). |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human OSTM1 protein (TMPY-01194) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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