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Gunagratinib

Name: Gunagratinib
Brand: TargetMol
SKU: T39682
Price: 66 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T39682Cas No. 2211082-53-8

Alias ICP-192, ICP192

Gunagratinib (ICP-192) is an orally active and highly effective pan-FGFR (fibroblast growth factor receptor) inhibitor, used in studies of FGFR-related diseases.

Gunagratinib

🥰Excellent

Purity: 99.68%

Catalog No. T39682Alias ICP-192, ICP192Cas No. 2211082-53-8

Gunagratinib (ICP-192) is an orally active and highly effective pan-FGFR (fibroblast growth factor receptor) inhibitor, used in studies of FGFR-related diseases.

Pack Size	Price	Availability
1 mg	$66	In Stock
5 mg	$158	In Stock
10 mg	$248	In Stock
25 mg	$397	In Stock
50 mg	$569	In Stock
100 mg	$786	In Stock
1 mL x 10 mM (in DMSO)	$176	In Stock

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Batch Information

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Purity:99.68%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Gunagratinib (ICP-192) is an orally active and highly effective pan-FGFR (fibroblast growth factor receptor) inhibitor, used in studies of FGFR-related diseases.
In vitro	Gunagratinib is a novel pan-FGFR (fibroblast growth factor receptor) inhibitor that effectively and selectively irreversibly inhibits FGFR activity through covalent binding with antitumor activity. [1]
Synonyms	ICP-192, ICP192

Chemical Properties

Molecular Weight	423.47
Formula	C₂₂H₂₅N₅O₄
Cas No.	2211082-53-8
Smiles	N(C)C=1N(N=C(C#CC2=CC(OC)=CC(OC)=C2)C1C(N)=O)[C@@H]3CN(C(C=C)=O)CC3
Relative Density.	1.27 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80.00 mg/mL (188.92 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3614 mL	11.8072 mL	23.6144 mL	118.0721 mL
5 mM	0.4723 mL	2.3614 mL	4.7229 mL	23.6144 mL
10 mM	0.2361 mL	1.1807 mL	2.3614 mL	11.8072 mL
20 mM	0.1181 mL	0.5904 mL	1.1807 mL	5.9036 mL
50 mM	0.0472 mL	0.2361 mL	0.4723 mL	2.3614 mL
100 mM	0.0236 mL	0.1181 mL	0.2361 mL	1.1807 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc