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Oligomycin

Catalog No. T21494 CAS 1404-19-9

Oligomycin is an antifungal antibiotic that is an inhibitor of H+-ATP synthetase. The Oligomycin blocks oxidative phosphorylation and the electron transport chain. Oligomycin inhibited HIF-1alpha expression in hypoxic tumor cells.

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Oligomycin, CAS 1404-19-9

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Storage & Solubility Information

Description	Oligomycin is an antifungal antibiotic that is an inhibitor of H+-ATP synthetase. The Oligomycin blocks oxidative phosphorylation and the electron transport chain. Oligomycin inhibited HIF-1alpha expression in hypoxic tumor cells.
In vitro	Oligomycin, an inhibitor targeting the F0 component of H+-ATP synthase, exhibits suppressive effects on TNF-induced apoptosis. [1]

Molecular Weight	N/A
CAS No.	1404-19-9

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20 mg/mL, Sonication and heating are recommended.

References and Literature

1. Zhou W, et al. Membrane plasticity facilitates recognition of the inhibitor oligomycin by the mitochondrial ATP synthase rotor. Biochim Biophys Acta Bioenerg. 2018;1859(9):789-796. 2. SMITH RM, PETERSON WH, McCOY E. Oligomycin, a new antifungal antibiotic. Antibiot Chemother (Northfield). 1954;4(9):962-970. 3. López de Figueroa P, et al. Autophagy activation and protection from mitochondrial dysfunction in human chondrocytes. Arthritis Rheumatol. 2015;67(4):966-976.

Related compound libraries

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Inhibitor Library

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Keywords

Oligomycin 1404-19-9 Angiogenesis Chromatin/Epigenetic HIF Oligomycin Complex inhibitor inhibit

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