Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PD-1-IN-24 (compound 1) is an orally active PD-1 inhibitor.
Description | PD-1-IN-24 (compound 1) is an orally active PD-1 inhibitor. |
In vivo | PD-1-IN-24 (compound 1, 15mg/kg, orally, twice a day) demonstrates a tumor growth inhibition (TGI) of 19.96% in a subcutaneous 4T1 murine breast cancer model in BALB/c mice[1]. Additionally, at increased dosages, this compound exhibits dose-dependent tumor growth suppression in Bl6F10 models, achieving TGI percentages of 35.59% (30 mg/kg), 38.87% (60 mg/kg), and 47.35% (120 mg/kg), respectively[1]. |
Molecular Weight | 469.504 |
Formula | C27H26F3NO3 |
CAS No. | 2360909-50-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PD-1-IN-24 2360909-50-6 PD 1 IN 24 PD1IN24 inhibitor inhibit