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(Rac)-CP-601927 hydrochloride

Catalog No. T39833 CAS 230615-01-7

(Rac)-CP-601927 hydrochloride is the racemate form of CP-601927, which is a nicotinic acetylcholine receptor (nAChR) agonist. It exhibits Ki values of 1.2 nM and 102 nM for α4β2 and α3β4 nAChR, respectively.

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(Rac)-CP-601927 hydrochloride Chemical Structure

(Rac)-CP-601927 hydrochloride, CAS 230615-01-7

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	(Rac)-CP-601927 hydrochloride is the racemate form of CP-601927, which is a nicotinic acetylcholine receptor (nAChR) agonist. It exhibits Ki values of 1.2 nM and 102 nM for α4β2 and α3β4 nAChR, respectively.
In vitro	CP-601927 has been shown to elicit notable antidepressant-like effects in mice. It achieves this by either decreasing cholinergic signaling through diminished efficacy or by desensitizing α4β2* nAChRs[1].

Molecular Weight	263.69
Formula	C12H13ClF3N
CAS No.	230615-01-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Yann S Mineur, et al. α4β2 nicotinic acetylcholine receptor partial agonists with low intrinsic efficacy have antidepressant-like properties. Behav Pharmacol. 2011 Aug;22(4):291-9.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

(Rac)-CP-601927 hydrochloride 230615-01-7 CP 601927 Hydrochloride CP601927 Hydrochloride (Rac)CP601927 hydrochloride CP-601927 Hydrochloride (Rac) CP 601927 hydrochloride inhibitor inhibit

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