(Rac)-CP-601927 hydrochloride

Name: (Rac)-CP-601927 hydrochloride
Brand: TargetMol
SKU: T39833
Rating: 4.5 (1 reviews)

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Catalog No. T39833Cas No. 230615-01-7

(Rac)-CP-601927 hydrochloride is the racemate form of CP-601927, a nicotinic acetylcholine receptor (nAChR) agonist, with Ki values of 1.2 nM for α4β2 and 102 nM for α3β4 nAChR.

(Rac)-CP-601927 hydrochloride

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Catalog No. T39833Cas No. 230615-01-7

(Rac)-CP-601927 hydrochloride is the racemate form of CP-601927, a nicotinic acetylcholine receptor (nAChR) agonist, with Ki values of 1.2 nM for α4β2 and 102 nM for α3β4 nAChR.

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Product Introduction

Bioactivity

Description	(Rac)-CP-601927 hydrochloride is the racemate form of CP-601927, a nicotinic acetylcholine receptor (nAChR) agonist, with Ki values of 1.2 nM for α4β2 and 102 nM for α3β4 nAChR.
In vitro	CP-601927 has been shown to elicit notable antidepressant-like effects in mice. It achieves this by either decreasing cholinergic signaling through diminished efficacy or by desensitizing α4β2* nAChRs[1].

Chemical Properties

Molecular Weight	263.69
Formula	C₁₂H₁₃ClF₃N
Cas No.	230615-01-7
Smiles	Cl.FC(F)(F)c1ccc2C3CC(CNC3)c2c1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc