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Anti-PHYH Antibody (3G140) is a Mouse antibody targeting PHYH. Anti-PHYH Antibody (3G140) can be used in IHC-P.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 μL | $199 | 7-10 days |
Description | Anti-PHYH Antibody (3G140) is a Mouse antibody targeting PHYH. Anti-PHYH Antibody (3G140) can be used in IHC-P. |
Alias | RD, phytanoyl-CoA 2-hydroxylase, PHYH1, PAHX, LNAP1, LN1 |
Ig Type | Monoclonal Mouse IgG1 |
Clone | 3G140 |
Reactivity | Human |
Verified Activity | Immunochemical staining of human PHYH in human kidney with mouse monoclonal antibody (1:30, formalin-fixed paraffin embedded sections). |
Application | IHC-P |
Recommended Dose | IHC-P: 1:20-1:100 |
Antibody Type | Monoclonal |
Host Species | Mouse |
Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human PHYH (rh PHYH; TMPY-03109; O14832; Ser31-Leu338). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
Purification | Protein A |
Appearance | Liquid |
Formulation | 0.2 μm filtered solution in PBS |
Research Background | PHYH belongs to the family of iron(II)-dependent oxygenases, which typically incorporate one atom of dioxygen into the substrate and one atom into the succinate carboxylate group. PHYH is expressed in liver, kidney, and T-cells, but not in spleen, brain, heart, lung and skeletal muscle. It converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA. Defects in PHYH can cause Refsum disease (RD). RD is an autosomal recessive disorder characterized clinically by a tetrad of abnormalities: retinitis pigmentosa, peripheral neuropathy, cerebellar ataxia, and elevated protein levels in the cerebrospinal fluid (CSF). Patients exhibit accumulation of the branched-chain fatty acid, phytanic acid, in blood and tissues. |
Conjucates | Unconjugated |
Immunogen | Recombinant Human PHYH Protein (TMPY-03109) |
Antigen Species | Human |
Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
Transport | Shipping with blue ice. |
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