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Anti-SPIRE2 Polyclonal Antibody

Catalog No. TMAB-13127 Copy Product Info
🥰Excellent
Anti-SPIRE2 Polyclonal Antibody is a Rabbit antibody targeting SPIRE2. Anti-SPIRE2 Polyclonal Antibody can be used in WB.

Anti-SPIRE2 Polyclonal Antibody

Copy Product Info
🥰Excellent
Catalog No. TMAB-13127

Anti-SPIRE2 Polyclonal Antibody is a Rabbit antibody targeting SPIRE2. Anti-SPIRE2 Polyclonal Antibody can be used in WB.

Anti-SPIRE2 Polyclonal Antibody
Pack SizePriceUSA StockGlobal StockQuantity
50 μL$2227-10 days7-10 days
100 μL$3737-10 days7-10 days
200 μL$5277-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-SPIRE2 Polyclonal Antibody is a Rabbit antibody targeting SPIRE2. Anti-SPIRE2 Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Mouse (predicted:Human,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep)
Verified Activity
Sample: Liver (Mouse) Lysate at 40 μg
Primary: Anti-SPIRE2 (TMAB-13127) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 80 kD
Observed band size: 80 kD
Application
WB
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationCytoplasm > cytoskeleton.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundSpir-2 is a 714 amino acid protein belonging to the spire family. Spir-2 is a cytoplasmic protein that contains one KIND domain and three WH2 domains. Spir-2 binds to actin via the WH2 domains and acts as an actin nucleation factor. Spir-2 is involved in vesicle transport and acts as a link between actin organization and intracellular transport. Spir-2 is expressed as four isoforms that are produced by alternative splicing events. The gene that encodes Spir-2 maps to human chromosome 16, which encodes over 900 genes and approximately 90 million base pairs, making up nearly 3% of human cellular DNA. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, though through the CREBBP gene which encodes a critical CREB binding protein. Signs of Rubinstein-Taybi include mental retardation and predisposition to tumor growth and white blood cell neoplasias. Crohn's disease is a gastrointestinal inflammatory condition associated with chromosome 16 through the NOD2 gene.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human SPIRE2
Antigen Species
Human
Gene Name
SPIRE2
Gene ID
84501
Protein Name
Protein spire homolog 2
Uniprot ID
Q8WWL2
Function
Acts as a actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in vesicle transport processes providing a novel link between actin organization and intracellular transport.
Chemical Properties
Molecular WeightTheoretical: 80 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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