Tos-PEG12-Tos

Name: Tos-PEG12-Tos
Brand: TargetMol
SKU: T18848
Rating: 4.5 (1 reviews)

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Catalog No. T18848Cas No. 1456708-45-4

Tos-PEG12-Tos is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands [Tosyl(Tos)] critical for the formation of PROTAC molecules, and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Tos-PEG12-Tos

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Catalog No. T18848Cas No. 1456708-45-4

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	Inquiry	Backorder	Backorder
500 mg	Inquiry	Backorder	Backorder

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	Tos-PEG12-Tos is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands [Tosyl(Tos)] critical for the formation of PROTAC molecules, and enabling selective protein degradation via the ubiquitin-proteasome system within cells.
In vitro	PROTACs are compounds that use a linker to connect two distinct ligands: one binding to an E3 ubiquitin ligase and the other to the target protein. They leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1].

Chemical Properties

Molecular Weight	855.02
Formula	C₃₈H₆₂O₁₇S₂
Cas No.	1456708-45-4
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc