ANGPTL4 Protein, Human, Recombinant (His)

Name: ANGPTL4 Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPY-03523
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: UNQ171, TGQTL, pp1158, PGAR, NL2, HFARP, HARP, FIAF, ARP4, ANGPTL2, angiopoietin-like 4) Copy Product Info

Synonyms: UNQ171, TGQTL, pp1158, PGAR, NL2, HFARP, HARP, FIAF, ARP4, ANGPTL2, angiopoietin-like 4

Catalog No. TMPY-03523 Copy Product Info

ANGPTL4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29.5 kDa and the accession number is Q9BY76.

Pack Size	Price	USA Stock	Global Stock
5 µg	$37	-	In Stock
10 µg	$56	-	In Stock
20 µg	$88	7-10 days	7-10 days
50 µg	$166	7-10 days	7-10 days
100 µg	$276	-	In Stock
200 µg	$489	7-10 days	7-10 days
500 µg	$1,030	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:94%

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	ANGPTL4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29.5 kDa and the accession number is Q9BY76.
Species	Human
Expression System	HEK293 Cells
Tag	N-His
Accession Number	Q9BY76
Construction	A DNA sequence encoding the human ANGPTL4 (Q9BY76) (Pro166-Ser406) was expressed with an N-terminal polyhistidine tag. Predicted N terminal: His
Protein Purity	> 95 % as determined by SDS-PAGE
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
Synonyms	UNQ171, TGQTL, pp1158, PGAR, NL2, HFARP, HARP, FIAF, ARP4, ANGPTL2, angiopoietin-like 4
Research Background	ANGPTL4, also known as ANGPTL2, is a protein with hypoxia-induced expression in endothelial cells. It contains 1 fibrinogen C-terminal domain and is expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney. ANGPTL4 inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. It may act as a regulator of angiogenesis and modulate tumorigenesis. It inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. It may also exert a protective function on endothelial cells through an endocrine action. ANGPTL4 is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.

Chemical Properties

Molecular Weight

29.5 kDa (predicted); 35 kDa (reducing condition, due to glycosylation)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.