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Lawsone methyl ether

Name: Lawsone methyl ether
Brand: TargetMol
SKU: T3008
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T3008Cas No. 2348-82-5

Alias 2-Methoxy-p-naphthoquinone, 2-Methoxynaphthoquinone, 2-Methoxy-1,4-naphthoquinone

Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone) induces apoptosis in A549 cells independently of cell cycle arrest, mediated by JNK and p38 MAPK signaling pathways. These pathways are activated due to oxidative DNA damage from increased ROS generation in MNQ-treated A549 cells.

Lawsone methyl ether

🥰Excellent

Purity: 99.68%

Catalog No. T3008Alias 2-Methoxy-p-naphthoquinone, 2-Methoxynaphthoquinone, 2-Methoxy-1,4-naphthoquinoneCas No. 2348-82-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$33	In Stock	In Stock
200 mg	$46	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.68%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone) induces apoptosis in A549 cells independently of cell cycle arrest, mediated by JNK and p38 MAPK signaling pathways. These pathways are activated due to oxidative DNA damage from increased ROS generation in MNQ-treated A549 cells.
Synonyms	2-Methoxy-p-naphthoquinone, 2-Methoxynaphthoquinone, 2-Methoxy-1,4-naphthoquinone

Chemical Properties

Molecular Weight	188.18
Formula	C₁₁H₈O₃
Cas No.	2348-82-5
Smiles	COC1=CC(=O)c2ccccc2C1=O
Relative Density.	1.2100 g/cm3 (Estimated)

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (53.14 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.3141 mL	26.5703 mL	53.1406 mL	265.7031 mL
5 mM	1.0628 mL	5.3141 mL	10.6281 mL	53.1406 mL
10 mM	0.5314 mL	2.6570 mL	5.3141 mL	26.5703 mL
20 mM	0.2657 mL	1.3285 mL	2.6570 mL	13.2852 mL
50 mM	0.1063 mL	0.5314 mL	1.0628 mL	5.3141 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc