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Anti-BACE1 Antibody-PE (8D358)

🥰Excellent
Catalog No. TMAY-00206P

Anti-BACE1 Antibody-PE (8D358) is a PE-conjugated Rabbit antibody targeting BACE1. Anti-BACE1 Antibody-PE (8D358) can be used in FCM.

Anti-BACE1 Antibody-PE (8D358)

Anti-BACE1 Antibody-PE (8D358)

🥰Excellent
Catalog No. TMAY-00206P
Anti-BACE1 Antibody-PE (8D358) is a PE-conjugated Rabbit antibody targeting BACE1. Anti-BACE1 Antibody-PE (8D358) can be used in FCM.
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Product Introduction

Bioactivity
Description
Anti-BACE1 Antibody-PE (8D358) is a PE-conjugated Rabbit antibody targeting BACE1. Anti-BACE1 Antibody-PE (8D358) can be used in FCM.
Ig Type
Monoclonal Rabbit IgG
Clone
8D358
Reactivity
Human
Verified Activity
Flow cytometric analysis of Human BACE1 expression in Jurkat cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), and then stained with PE Rabbit anti-BACE1. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Application
FCM
Recommended Dose
5 μl/Test, 0.1 mg/ml
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionThis antibody was obtained from a rabbit immunized with purified, recombinant Human BACE1 / ASP2 (rh BACE1 / ASP2; TMPY-00752; NP_036236.1; Met 1-Thr 457) and conjugated with PE under optimum conditions, the unreacted PE was removed.
PurificationProtein A
AppearanceLiquid
FormulationPBS solution containing 0.5% BSA and 0.03%ProClin300
Research BackgroundBeta-site APP-cleaving enzyme 1 (BACE1) is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. In the brain, This protein is expressed highly in the substantia nigra, locus coruleus and medulla oblongata. Strong BACE1 expression has also been described in pancreatic tissue. BACE1 has a pivotal role in the pathogenesis of Alzheimer's disease. In Alzheimer's disease patients, BACE1 levels were elevated although mRNA levels were not changed. It has been found that BACE1 gene expression is controlled by a TATA-less promoter. The translational repression as a new mechanism controlling its expression. And the low concentrations of Ca(2+) (microM range) significantly increased the proteolytic activity of BACE1. Furthermore, BACE1 protein is ubiquitinated, and the degradation of BACE1 proteins and amyloid precursor protein processing are regulated by the ubiquitin-proteasome pathway. It has also been identified as the rate limiting enzyme for amyloid-beta-peptide (Abeta) production.
Related Conjugates and Formulations
Conjucates
PE
Others Formats
Unconjugated/FITC
Antibody Types Available
3
Antigen Details
Immunogen
Recombinant Human BACE1 / ASP2 protein (TMPY-00752)
Antigen Species
Human
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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