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FGFR2 Protein, Human, Recombinant (aa 1-378, His)

Catalog No. TMPY-04273
Synonyms: TK25, ECT1, JWS, fibroblast growth factor receptor 2, CD332, CEK3, K-SAM, BFR-1, BBDS, KGFR, CFD1, TK14, BEK

FGFR2 Protein, Human, Recombinant (aa 1-378, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 41.1 kDa and the accession number is P21802-3.

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FGFR2 Protein, Human, Recombinant (aa 1-378, His)
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200 μg 5 days $ 904.00
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Biological Description
Technical Params
Product Properties
References and Literature
Description FGFR2 Protein, Human, Recombinant (aa 1-378, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 41.1 kDa and the accession number is P21802-3.
Species Human
Expression System HEK293 Cells
Tag C-His
Accession Number P21802-3
Synonyms TK25, ECT1, JWS, fibroblast growth factor receptor 2, CD332, CEK3, K-SAM, BFR-1, BBDS, KGFR, CFD1, TK14, BEK
Construction The Human FGFR2-alpha(IIIb) (NP_075259.4) (Met1-Glu378) was expressed with a polyhistidine tag at the C-terminus.
Protein Purity ≥ 95 % as determined by SDS-PAGE.≥90 % as determined by SEC-HPLC.
Molecular Weight 41.1 kDa (predicted)
Endotoxin < 1.0 EU/μg of the protein as determined by the LAL method.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. It is required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. FGFR2 plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. It also promotes cell proliferation in keratinocytes and imature osteoblasts, but promotes apoptosis in differentiated osteoblasts. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal CD332 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. Defects in CD3322 are the cause of Crouzon syndrome, Jackson-Weiss syndrome, Apert syndrome, Pfeiffer syndrome, Beare-Stevenson cutis gyrata syndrome, familial scaphocephaly syndrome, lacrimo-auriculo-dento-digital syndrome and Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

References and Literature

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Keywords

FGFR2 Protein, Human, Recombinant (aa 1-378, His) CFD-1 CD-332 BFR1 TK25 ECT1 JWS CEK-3 fibroblast growth factor receptor 2 BFR 1 CD332 TK-14 CEK3 TK-25 TK 25 CD 332 K-SAM BFR-1 BBDS KGFR CFD1 TK14 TK 14 CEK 3 BEK CFD 1 ECT-1 ECT 1 recombinant recombinant-proteins proteins protein

 

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