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P-1075

Name: P-1075
Brand: TargetMol
SKU: T16420
Price: 55 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16420Cas No. 60559-98-0

P-1075 is a potent sulfonylurea receptor 2-associated ATP-sensitive potassium channels (SUR2-KIR6) activator (EC50 = 45 nM). P-1075 opens opens mitoKATP channels and may be cardioprotective.

P-1075

🥰Excellent

Purity: 99.85%

Catalog No. T16420Cas No. 60559-98-0

P-1075 is a potent sulfonylurea receptor 2-associated ATP-sensitive potassium channels (SUR2-KIR6) activator (EC50 = 45 nM). P-1075 opens opens mitoKATP channels and may be cardioprotective.

Pack Size	Price	Availability
1 mg	$55	In Stock
5 mg	$128	In Stock
10 mg	$213	In Stock
25 mg	$388	In Stock
50 mg	$589	In Stock
100 mg	$787	In Stock
200 mg	$1,070	In Stock
1 mL x 10 mM (in DMSO)	$97	In Stock

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Batch Information

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Purity:99.85%

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COA LCMS

Product Introduction

Bioactivity

Description	P-1075 is a potent sulfonylurea receptor 2-associated ATP-sensitive potassium channels (SUR2-KIR6) activator (EC50 = 45 nM). P-1075 opens opens mitoKATP channels and may be cardioprotective.
Targets&IC50	SUR2-KIR6:45 nM(EC50)

Chemical Properties

Molecular Weight	231.3
Formula	C₁₂H₁₇N₅
Cas No.	60559-98-0
Smiles	CCC(C)(C)N\C(NC#N)=N\c1cccnc1
Relative Density.	1.07 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (1080.85 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (21.62 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3234 mL	21.6169 mL	43.2339 mL	216.1695 mL
5 mM	0.8647 mL	4.3234 mL	8.6468 mL	43.2339 mL
10 mM	0.4323 mL	2.1617 mL	4.3234 mL	21.6169 mL
20 mM	0.2162 mL	1.0808 mL	2.1617 mL	10.8085 mL
50 mM	0.0865 mL	0.4323 mL	0.8647 mL	4.3234 mL
100 mM	0.0432 mL	0.2162 mL	0.4323 mL	2.1617 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc