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ATTECs

AuTophagy-TEthering Compounds (ATTECs) are a novel class of bifunctional molecules proposed to hijack the autophagosomal pathway for the degradation of potentially any cellular components in addition to proteins. Targeting stored fats in cells with LD·ATTECs suggests a novel approach to combating diseases implicating accumulation of lipid droplets, such as obesity, cardiovascular diseases, or cancer.

  • LC3-mHTT-IN-AN1
    T8081486443-73-6
    LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B. LC3-mHTT-IN-AN1 targeted mHTT to autophagosomes reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.
    • $119
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  • LC3-mHTT-IN-AN2
    T50707758-73-8
    LC3-mHTT-IN-AN2 (5,7-Dihydroxy-4-phenylcoumarin) is found in the plant Passiflora serratodigitata with the antibacterial activity.
    • $41
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