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MK-0686

Name: MK-0686
Brand: TargetMol
SKU: T33421
Price: 115 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T33421Cas No. 578727-68-1

Alias MK0686

MK-0686 is an orally available bradykinin B1 receptor antagonist with potential anti-inflammatory activity.

MK-0686

🥰Excellent

Purity: 99.7%

Catalog No. T33421Alias MK0686Cas No. 578727-68-1

MK-0686 is an orally available bradykinin B1 receptor antagonist with potential anti-inflammatory activity.

Pack Size	Price	Availability
1 mg	$115	In Stock
5 mg	$282	In Stock
10 mg	$413	In Stock
25 mg	$648	In Stock
50 mg	$922	In Stock
100 mg	$1,260	In Stock
200 mg	$1,690	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.7%

Resource Download

COA FNMR HNMR LCMS

Product Introduction

Bioactivity

Description	MK-0686 is an orally available bradykinin B1 receptor antagonist with potential anti-inflammatory activity.
Synonyms	MK0686

Chemical Properties

Molecular Weight	486.84
Formula	C₂₂H₁₉ClF₄N₂O₄
Cas No.	578727-68-1
Smiles	C(N[C@H](C)C1=C(F)C=C(C=C1)C2=C(C(OC)=O)C(Cl)=CC=C2)(=O)C3(NC(C(F)(F)F)=O)CC3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (102.7 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0541 mL	10.2703 mL	20.5406 mL	102.7031 mL
5 mM	0.4108 mL	2.0541 mL	4.1081 mL	20.5406 mL
10 mM	0.2054 mL	1.0270 mL	2.0541 mL	10.2703 mL
20 mM	0.1027 mL	0.5135 mL	1.0270 mL	5.1352 mL
50 mM	0.0411 mL	0.2054 mL	0.4108 mL	2.0541 mL
100 mM	0.0205 mL	0.1027 mL	0.2054 mL	1.0270 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc