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PSI-7409 tetrasodium

Name: PSI-7409 tetrasodium
Brand: TargetMol
SKU: T13852
Price: 213 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13852Cas No. 1621884-22-7

Alias PSI7409 tetrasodium, PSI 7409 tetrasodium

PSI-7409 tetrasodium is the pharmacologically active 5′-triphosphate metabolite of sofosbuvir (PSI-7977) that directly inhibits hepatitis C virus NS5B RNA-dependent RNA polymerase, with IC50 values of 1.6, 2.8, 0.7, and 2.6 μM against GT 1b_Con1, GT 2a_JFH1, GT 3a, and GT 4a NS5B polymerases, respectively, PSI-7409 tetrasodium is widely used to study antiviral mechanisms and genotype-specific polymerase inhibition.

PSI-7409 tetrasodium

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Purity: 99.97%

Catalog No. T13852Alias PSI7409 tetrasodium, PSI 7409 tetrasodiumCas No. 1621884-22-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$213	-	In Stock
5 mg	$645	-	In Stock
10 mg	$987	-	In Stock
25 mg	$1,520	-	In Stock
50 mg	$1,980	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.97%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	PSI-7409 tetrasodium is the pharmacologically active 5′-triphosphate metabolite of sofosbuvir (PSI-7977) that directly inhibits hepatitis C virus NS5B RNA-dependent RNA polymerase, with IC50 values of 1.6, 2.8, 0.7, and 2.6 μM against GT 1b_Con1, GT 2a_JFH1, GT 3a, and GT 4a NS5B polymerases, respectively, PSI-7409 tetrasodium is widely used to study antiviral mechanisms and genotype-specific polymerase inhibition.
Targets&IC50	GT2a JFH1:2.8 μM , GT3a:0.7 μM , GT4a:2.6 μM , GT1b Con1:1.6 μM
In vitro	In enzymatic assays, PSI-7409 tetrasodium inhibited HCV NS5B polymerase with IC50 values ranging from 0.7 to 2.8 μM across various genotypes [1].
Synonyms	PSI7409 tetrasodium, PSI 7409 tetrasodium

Chemical Properties

Molecular Weight	588.09
Formula	C₁₀H₁₂FN₂Na₄O₁₄P₃
Cas No.	1621884-22-7
Smiles	C[C@@]1([C@H](N2C(NC(C=C2)=O)=O)O[C@@H]([C@H]1O)COP(OP(OP([O-])([O-])=O)([O-])=O)([O-])=O)F.[Na+].[Na+].[Na+].[Na+]
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 80 mg/mL (136.03 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.7004 mL	8.5021 mL	17.0042 mL	85.0210 mL
5 mM	0.3401 mL	1.7004 mL	3.4008 mL	17.0042 mL
10 mM	0.1700 mL	0.8502 mL	1.7004 mL	8.5021 mL
20 mM	0.0850 mL	0.4251 mL	0.8502 mL	4.2511 mL
50 mM	0.0340 mL	0.1700 mL	0.3401 mL	1.7004 mL
100 mM	0.0170 mL	0.0850 mL	0.1700 mL	0.8502 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc