Tos-aminoxy-Boc-PEG4-Tos

Name: Tos-aminoxy-Boc-PEG4-Tos
Brand: TargetMol
SKU: T17119
Rating: 4.5 (1 reviews)

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Catalog No. T17119Cas No. 1817735-42-4

Tos-aminoxy-Boc-PEG4-Tos is a PEG4-based PROTAC linker used for synthesizing PROTACs [1].

Tos-aminoxy-Boc-PEG4-Tos

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Catalog No. T17119Cas No. 1817735-42-4

Tos-aminoxy-Boc-PEG4-Tos is a PEG4-based PROTAC linker used for synthesizing PROTACs [1].

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Product Introduction

Bioactivity

Description	Tos-aminoxy-Boc-PEG4-Tos is a PEG4-based PROTAC linker used for synthesizing PROTACs [1].
In vitro	PROTACs consist of two ligands linked together: one targeting an E3 ubiquitin ligase and the other targeting the specific protein. They utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Chemical Properties

Molecular Weight	617.73
Formula	C₂₇H₃₉NO₁₁S₂
Cas No.	1817735-42-4
Relative Density.	1.259 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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