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PI4KIIIbeta-IN-10

🥰Excellent
Catalog No. T12468Cas No. 1881233-39-1

PI4KIIIbeta-IN-10 is a potent inhibitor of PI4KIIIβ with an IC50 value of 3.6 nM.

PI4KIIIbeta-IN-10

PI4KIIIbeta-IN-10

🥰Excellent
Purity: 99.76%
Catalog No. T12468Cas No. 1881233-39-1
PI4KIIIbeta-IN-10 is a potent inhibitor of PI4KIIIβ with an IC50 value of 3.6 nM.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$73In StockIn Stock
5 mg$167In StockIn Stock
10 mg$268In StockIn Stock
25 mg$443In StockIn Stock
50 mg$592-In Stock
100 mg$833-In Stock
200 mg$1,120-In Stock
1 mL x 10 mM (in DMSO)$176In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.76%
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COA HNMR HPLC LCMS

Product Introduction

Bioactivity
Description
PI4KIIIbeta-IN-10 is a potent inhibitor of PI4KIIIβ with an IC50 value of 3.6 nM.
Targets&IC50
PI3Kα:10 μM, PI4KIIIα:3 μM, PI3Kδ:720 nM, PI3Kγ:20 μM, PI4KIIIβ:3.6 nM, PI3KC2γ:1 μM
In vitro
The most potent of these molecules (PI4KIIIbeta-IN-10；compound 10) was screened over a panel of nine related lipid kinases and was >200 fold selective for PI4KIIIβ across all enzymes tested. Two of the most potent and selective molecules (compound 9+10) were also the most effective antiviral compounds in a cellular model of Hepatitis C virus replication, with the best balance of antiviral potency and low cellular toxicity. PI4KIIIbeta-IN-10 shows weak inhibition of PI3KC2γ (IC50 ~1 μM), PI3Kα (~10 μM), and PI4KIIIα (~3 μM), and <20% inhibition at concentrations up to 20 μM for PI4K2α, PI4K2β, and PI3Kβ[1].
Chemical Properties
Molecular Weight475.58
FormulaC22H25N3O5S2
Cas No.1881233-39-1
SmilesCOc1ccc(cc1S(=O)(=O)Nc1ccc(O)cc1)-c1sc(NC(=O)C(C)(C)C)nc1C
Relative Density.1.367 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 30 mg/mL (63.08 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.21 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1027 mL10.5135 mL21.0270 mL105.1348 mL
5 mM0.4205 mL2.1027 mL4.2054 mL21.0270 mL
10 mM0.2103 mL1.0513 mL2.1027 mL10.5135 mL
20 mM0.1051 mL0.5257 mL1.0513 mL5.2567 mL
50 mM0.0421 mL0.2103 mL0.4205 mL2.1027 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PI4KIIIβ-IN-10PI4KIIIβPI4KIIIαPI4KIIIb-IN-10PI4KIIIbeta-IN-10PI-4KIIIbeta-IN-10PI4KIIIbetaIN10PI4KIIIbeta IN 10PI4KPI4 kinasesPI3KδPI3KγPI3KαPI3KC2γPhosphatidylinositol 4 kinasesInhibitorinhibit
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