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Lobetyolinin

Name: Lobetyolinin
Brand: TargetMol
SKU: TN1876
Price: 106 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1876Cas No. 142451-48-7

Lobetyolinin is a compound from Codonopsis pilosula with acetylcholinesterase (AChE) inhibitory and antiarrhythmic activities.

Lobetyolinin

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Purity: 99.72%

Catalog No. TN1876Cas No. 142451-48-7

Lobetyolinin is a compound from Codonopsis pilosula with acetylcholinesterase (AChE) inhibitory and antiarrhythmic activities.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$106	-	In Stock
5 mg	$289	In Stock	In Stock
10 mg	$433	In Stock	In Stock
25 mg	$689	-	In Stock
50 mg	$976	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.72%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

Lobetyolinin is a compound from Codonopsis pilosula with acetylcholinesterase (AChE) inhibitory and antiarrhythmic activities.

In vivo

METHODS: Lobetyolinin (50 μM, 24 hours) was used to treat zebrafish larvae with 15 μM terfenadine for 2 hours, and the heartbeat was recorded under fluorescence.
RESULTS:As a result, the heart rate of zebrafish larvae recovered to varying degrees, and Lobetyolinin showed better activity. [1]
METHODS: After 1 hour of treatment with 25 μM terfenadine, the heart rate decreased and irregular rhythm appeared. After 6 hours of pretreatment with Lobetyolinin, the electrocardiogram of adult zebrafish treated with it was measured.
RESULTS:Lobetyolinin restored the heart rate of adult zebrafish, indicating that it has anti-arrhythmic effects. [1]

Chemical Properties

Molecular Weight	558.57
Formula	C₂₆H₃₈O₁₃
Cas No.	142451-48-7
Smiles	O([C@@H]([C@@H](C#CC#C/C=C/C)O)/C=C/CCCO)[C@@H]1O[C@H](CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@H](O)[C@H]1O
Relative Density.	1.48g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 80 mg/mL (143.22 mM), Sonication is recommended.

Solution Preparation Table

Ethanol

	1mg	5mg	10mg	50mg
1 mM	1.7903 mL	8.9514 mL	17.9029 mL	89.5143 mL
5 mM	0.3581 mL	1.7903 mL	3.5806 mL	17.9029 mL
10 mM	0.1790 mL	0.8951 mL	1.7903 mL	8.9514 mL
20 mM	0.0895 mL	0.4476 mL	0.8951 mL	4.4757 mL
50 mM	0.0358 mL	0.1790 mL	0.3581 mL	1.7903 mL
100 mM	0.0179 mL	0.0895 mL	0.1790 mL	0.8951 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc