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Vixarelimab (KPL-716) is a human anti-oncostatin M (OSM) monoclonal antibody with affinity for the beta chain of the OSM receptor and inhibition of IL-31 and OSM signaling.Vixarelimab can be used to study severe nodular itch and idiopathic pulmonary fibrosis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 372.00 | |
5 mg | In stock | $ 997.00 | |
10 mg | In stock | $ 1,590.00 |
Description | Vixarelimab (KPL-716) is a human anti-oncostatin M (OSM) monoclonal antibody with affinity for the beta chain of the OSM receptor and inhibition of IL-31 and OSM signaling.Vixarelimab can be used to study severe nodular itch and idiopathic pulmonary fibrosis. |
In vitro |
At a concentration of 0.0001 μg/mL, Vixarelimab (KPL-716) induces an increase in MCP-1/CCL2 levels in human epidermal keratinocytes (HEK) and human dermal fibroblasts (HDF). However, at concentrations of 0.001 μg/mL or higher, there is a significant decrease in MCP-1/CCL2 levels in both cell types[1]. Pre-treatment with Vixarelimab (KPL-716) (0.0001-0.1 μg/mL) reduces MCP-1/CCL2 levels in both HEK and HDF cells induced by Oncostatin M (OSM) and OSM + IL-4. The maximum effect is observed at concentrations of 0.01 μg/mL and 0.1 μg/mL[1]. |
Synonyms | RG-6536, RO-7622888, KPL-716 |
Molecular Weight | N/A |
CAS No. | 2243320-83-2 |
store at low temperature
store at -20°C
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Vixarelimab 2243320-83-2 Immunology/Inflammation Interleukin RG-6536 RO-7622888 KPL-716 inhibitor inhibit