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SMS 121

Name: SMS 121
Brand: TargetMol
SKU: T205876
Rating: 4.5 (1 reviews)

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Catalog No. T205876Cas No. 949875-48-3

Alias SMS121

SMS 121 is a novel CD36 inhibitor that impairs fatty acid uptake and cell viability in acute myeloid leukaemia (AML) cells.

SMS 121

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Purity: 98.29%

Catalog No. T205876Alias SMS121Cas No. 949875-48-3

SMS 121 is a novel CD36 inhibitor that impairs fatty acid uptake and cell viability in acute myeloid leukaemia (AML) cells.

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Purity:98.29%

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COA LCMS HNMR

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Product Introduction

Bioactivity

Description	SMS 121 is a novel CD36 inhibitor that impairs fatty acid uptake and cell viability in acute myeloid leukaemia (AML) cells.
Targets&IC50	KG-1 cells:156 µM
In vitro	Methods: KG-1 cells were treated with SMS 121 (0-400 µM, 72 hours), and cell viability was measured by ATP assay. Results: SMS 121 inhibited KG-1 cell viability with an IC50 value of 156 µM. [1]
Alias	SMS121

Chemical Properties

Molecular Weight	355.38
Formula	C₂₀H₂₁NO₅
Cas No.	949875-48-3
Smiles	O=C(O)COC1=CC=C(C=CC(=O)C2=CC=C(C=C2)N(C)C)C=C1OC
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | store at 4°C | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (28.14 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8139 mL	14.0694 mL	28.1389 mL	140.6945 mL
5 mM	0.5628 mL	2.8139 mL	5.6278 mL	28.1389 mL
10 mM	0.2814 mL	1.4069 mL	2.8139 mL	14.0694 mL
20 mM	0.1407 mL	0.7035 mL	1.4069 mL	7.0347 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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