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Desmosterol
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Catalog No. T19711Cas No. 313-04-2
Alias Desmesterol, 24-Dehydrocholesterol
Desmosterol (24-Dehydrocholesterol) is a cholesterol biosynthesis intermediate that inhibits macrophage inflammatory vesicle activation and prevents vascular inflammation and atherosclerosis.
Desmosterol
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Catalog No. T19711Alias Desmesterol, 24-DehydrocholesterolCas No. 313-04-2
Desmosterol (24-Dehydrocholesterol) is a cholesterol biosynthesis intermediate that inhibits macrophage inflammatory vesicle activation and prevents vascular inflammation and atherosclerosis.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $35 | - | In Stock | |
| 5 mg | $55 | In Stock | In Stock | |
| 10 mg | $83 | - | In Stock | |
| 25 mg | Preferential | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:>99.99%
Appearance:Solid
Color:White
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Product Introduction
Desmosterol AI Summary
Desmosterol exhibits cytotoxicity against mouse P388 cells with an ED50 value of 33.53 µg ml⁻¹ as determined by the MTT assay, but shows ED50 values greater than 50.0 µg ml⁻¹ against human KB, A549, and HT29 cells in the same assay. It demonstrates bioactivity in Mycobacterium tuberculosis CYP enzymes, particularly CYP124A1, CYP125A1, and CYP142A1, with the highest turnover rate observed for CYP125A1 (13.29 /min). The compound's activity relative to cholesterol is highest for CYP124A1 (91.2%). Additionally, Desmosterol shows potent agonist activity at the Gal4-fused RORγt DNA binding domain in 293T cells, with an EC50 value of 80.0 nM as assessed by SRC1 coactivator recruitment in the presence of ursolic acid in a TR-FRET assay. It also acts as an orthosteric agonist at the recombinant human N-terminal His6-tagged RORγt ligand binding domain, displaying substantial binding affinity and variable effects on protein stability, indicated by changes in melting temperature (ΔTm) in the presence of different ligands. These results suggest that Desmosterol has modulatory effects on RORγt activity and protein stability..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Desmosterol (24-Dehydrocholesterol) is a cholesterol biosynthesis intermediate that inhibits macrophage inflammatory vesicle activation and prevents vascular inflammation and atherosclerosis. |
| Synonyms | Desmesterol, 24-Dehydrocholesterol |
| Molecular Weight | 384.64 |
| Formula | C27H44O |
| Cas No. | 313-04-2 |
| Smiles | C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(=CC3)C[C@@H](O)CC4)(CC1)[H])[H])(CC[C@@]2([C@@H](CCC=C(C)C)C)[H])[H] |
| Relative Density. | 1.00 g/cm3 (Predicted) |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | H2O: <0.1 mg/mL (Insoluble) DMF: 10 mg/mL (26 mM), Sonication is recommended. DMSO: 1 mg/mL (2.6 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO/DMF
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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