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LYS006

Name: LYS006
Brand: TargetMol
SKU: T9690
Price: 68 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9690Cas No. 1799681-85-8

Alias LYS 006, LTA4H-IN-1

LYS006 is a highly efficient and selective LTA4H (leukotriene A4 hydrolase) inhibitor, which can be used for neutrophil-driven inflammatory diseases such as ulcerative colitis.

LYS006

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Purity: 99.33%

Catalog No. T9690Alias LYS 006, LTA4H-IN-1Cas No. 1799681-85-8

LYS006 is a highly efficient and selective LTA4H (leukotriene A4 hydrolase) inhibitor, which can be used for neutrophil-driven inflammatory diseases such as ulcerative colitis.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$68	-	In Stock
5 mg	$163	-	In Stock
10 mg	$278	-	In Stock
25 mg	$553	-	In Stock
50 mg	$893	-	In Stock
100 mg	$1,420	-	In Stock
200 mg	$1,890	-	In Stock
1 mL x 10 mM (in DMSO)	$179	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.33%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	LYS006 is a highly efficient and selective LTA4H (leukotriene A4 hydrolase) inhibitor, which can be used for neutrophil-driven inflammatory diseases such as ulcerative colitis.
In vitro	Method: In vitro assays were conducted to evaluate the inhibitory effect of LYS006 on LTA4H enzymatic activity using Arg-AMC (arginine conjugated with 7-amino-4-methylcoumarin) as the substrate, with an incubation time of 15 minutes. Additionally, a human whole blood (hWB) assay was performed with a 30-minute treatment to assess the inhibition of LTB4 biosynthesis. Result: LYS006 effectively inhibited the hydrolysis of Arg-AMC catalyzed by LTA4H within 15 minutes, with an IC₅₀ of 2 nM. In the hWB assay, 30-minute treatment with LYS006 inhibited LTB4 biosynthesis, with an IC₅₀ of 167 nM. [1]
In vivo	Method: Mice were administered a single oral dose of LYS006 (0.3 mg/kg), and the inhibition of LTB4 release was evaluated in comparison to the vehicle control group. Result: LYS006 inhibited approximately 43% of LTB4 release compared to the vehicle control group. [1]
Synonyms	LYS 006, LTA4H-IN-1

Chemical Properties

Molecular Weight	392.77
Formula	C₁₆H₁₄ClFN₆O₃
Cas No.	1799681-85-8
Smiles	C([C@H](CC(O)=O)N)N1N=C(N=N1)C2=CC=C(OC3=C(F)C=C(Cl)C=N3)C=C2
Relative Density.	1.60 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: <1 mg/mL (insoluble)

DMSO: 80 mg/mL (203.68 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.4 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5460 mL	12.7301 mL	25.4602 mL	127.3010 mL
5 mM	0.5092 mL	2.5460 mL	5.0920 mL	25.4602 mL
10 mM	0.2546 mL	1.2730 mL	2.5460 mL	12.7301 mL
20 mM	0.1273 mL	0.6365 mL	1.2730 mL	6.3650 mL
50 mM	0.0509 mL	0.2546 mL	0.5092 mL	2.5460 mL
100 mM	0.0255 mL	0.1273 mL	0.2546 mL	1.2730 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc