Shopping Cart

Your shopping cart is currently empty

LYS006

Name: LYS006
Brand: TargetMol
SKU: T9690
Price: 68 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T9690Cas No. 1799681-85-8

Alias LYS 006, LTA4H-IN-1

LYS006 is a highly efficient and selective LTA4H (leukotriene A4 hydrolase) inhibitor, which can be used for neutrophil-driven inflammatory diseases such as ulcerative colitis.

LYS006

🥰Excellent

Purity: 99.33%

Catalog No. T9690Alias LYS 006, LTA4H-IN-1Cas No. 1799681-85-8

LYS006 is a highly efficient and selective LTA4H (leukotriene A4 hydrolase) inhibitor, which can be used for neutrophil-driven inflammatory diseases such as ulcerative colitis.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$68	-	In Stock
5 mg	$163	-	In Stock
10 mg	$278	-	In Stock
25 mg	$553	-	In Stock
50 mg	$893	-	In Stock
100 mg	$1,420	-	In Stock
200 mg	$1,890	-	In Stock
1 mL x 10 mM (in DMSO)	$179	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.33%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	LYS006 is a highly efficient and selective LTA4H (leukotriene A4 hydrolase) inhibitor, which can be used for neutrophil-driven inflammatory diseases such as ulcerative colitis.
In vitro	Method: In vitro assays were conducted to evaluate the inhibitory effect of LYS006 on LTA4H enzymatic activity using Arg-AMC (arginine conjugated with 7-amino-4-methylcoumarin) as the substrate, with an incubation time of 15 minutes. Additionally, a human whole blood (hWB) assay was performed with a 30-minute treatment to assess the inhibition of LTB4 biosynthesis. Result: LYS006 effectively inhibited the hydrolysis of Arg-AMC catalyzed by LTA4H within 15 minutes, with an IC₅₀ of 2 nM. In the hWB assay, 30-minute treatment with LYS006 inhibited LTB4 biosynthesis, with an IC₅₀ of 167 nM. [1]
In vivo	Method: Mice were administered a single oral dose of LYS006 (0.3 mg/kg), and the inhibition of LTB4 release was evaluated in comparison to the vehicle control group. Result: LYS006 inhibited approximately 43% of LTB4 release compared to the vehicle control group. [1]
Synonyms	LYS 006, LTA4H-IN-1

Chemical Properties

Molecular Weight	392.77
Formula	C₁₆H₁₄ClFN₆O₃
Cas No.	1799681-85-8
Smiles	C([C@H](CC(O)=O)N)N1N=C(N=N1)C2=CC=C(OC3=C(F)C=C(Cl)C=N3)C=C2
Relative Density.	1.60 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: <1 mg/mL (insoluble)

DMSO: 80 mg/mL (203.68 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.4 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5460 mL	12.7301 mL	25.4602 mL	127.3010 mL
5 mM	0.5092 mL	2.5460 mL	5.0920 mL	25.4602 mL
10 mM	0.2546 mL	1.2730 mL	2.5460 mL	12.7301 mL
20 mM	0.1273 mL	0.6365 mL	1.2730 mL	6.3650 mL
50 mM	0.0509 mL	0.2546 mL	0.5092 mL	2.5460 mL
100 mM	0.0255 mL	0.1273 mL	0.2546 mL	1.2730 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc