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Bonafton

Name: Bonafton
Brand: TargetMol
SKU: T8877
Price: 54 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8877Cas No. 6954-48-9

Alias Bonaphthone

Bonafton (Bonaphthone) is an antiviral agent.

Bonafton

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Catalog No. T8877Alias BonaphthoneCas No. 6954-48-9

Bonafton (Bonaphthone) is an antiviral agent.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$54	In Stock	In Stock
5 mg	$127	In Stock	In Stock
10 mg	$186	In Stock	In Stock
25 mg	$313	In Stock	In Stock
50 mg	$468	In Stock	In Stock
100 mg	$673	-	In Stock
200 mg	$938	-	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Appearance:Solid

Color:Orange

Resource Download

COA

Product Introduction

Bonafton AI Summary

Bonafton exhibits significant antiviral activity, particularly against SARS-CoV-2. It inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells by 7.39% at a concentration of 10 µM after 48 hours of treatment. Remarkably, it also demonstrates potent inhibition of the SARS-CoV-2 3CL-Pro protease, achieving inhibition percentages ranging from 100.58% to 104.26% at 20 µM, and has a low IC50 value of 40.0 nM for SARS-CoV-2 3CL-Pro protease inhibition. In contrast, its efficacy against the MERS_3CL Pro protease is much lower, with IC50 values exceeding 10000.0 nM. Additionally, Bonafton shows moderate inhibition of chymotrypsin at 10 µM, with an inhibition percentage of 8.47%. In terms of cytotoxicity inhibition on VERO-6 cells exposed to SARS-CoV-2, its performance is consistent but less robust, with inhibition percentages ranging from 0.33% to 0.43% at a 10 µM concentration after 48 hours. Furthermore, Bonafton inhibits human HDAC6 enzyme activity, with 48.55% inhibition using a commercial peptide substrate and -2.29% inhibition with a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Bonafton (Bonaphthone) is an antiviral agent.
Synonyms	Bonaphthone

Chemical Properties

Molecular Weight	237.05
Formula	C₁₀H₅BrO₂
Cas No.	6954-48-9
Smiles	BrC1=CC2=C(C=C1)C(=O)C(=O)C=C2
Relative Density.	1.708g/cm3

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 38.46 mg/mL (162.24 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2185 mL	21.0926 mL	42.1852 mL	210.9260 mL
5 mM	0.8437 mL	4.2185 mL	8.4370 mL	42.1852 mL
10 mM	0.4219 mL	2.1093 mL	4.2185 mL	21.0926 mL
20 mM	0.2109 mL	1.0546 mL	2.1093 mL	10.5463 mL
50 mM	0.0844 mL	0.4219 mL	0.8437 mL	4.2185 mL
100 mM	0.0422 mL	0.2109 mL	0.4219 mL	2.1093 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc