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Boc-MLF TFA (67247-12-5 free base) (Synonyms: Boc-MLF TFA, Boc-Met-Leu-Phe-OH (TFA))

Name: Boc-MLF TFA (67247-12-5 free base)
Brand: TargetMol
SKU: T10581
Rating: 4.5 (1 reviews)

Catalog No. T10581 Copy Product Info

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Boc-MLF (TFA) is a specific antagonist of formyl peptide receptor (FPR) and also inhibits signaling through FPRL1 at higher concentrations.

Boc-MLF TFA (67247-12-5 free base)

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Catalog No. T10581

Synonyms Boc-MLF TFA, Boc-Met-Leu-Phe-OH (TFA)

Boc-MLF (TFA) is a specific antagonist of formyl peptide receptor (FPR) and also inhibits signaling through FPRL1 at higher concentrations.

Pack Size	Price	USA Stock	Global Stock
25 mg	$1,520	6-8 weeks	6-8 weeks
50 mg	$1,980	6-8 weeks	6-8 weeks
100 mg	$2,500	6-8 weeks	6-8 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Boc-MLF (TFA) is a specific antagonist of formyl peptide receptor (FPR) and also inhibits signaling through FPRL1 at higher concentrations.
In vitro	Boc-MLF inhibits superoxide production induced by FPR agonist fMLF (EC50: 630 nM in neutrophils). Boc-MLF (25 μM) blocks FPRL1-agonist serum amyloid A (SAA) induced calcium response.
Synonyms	Boc-MLF TFA, Boc-Met-Leu-Phe-OH (TFA)

Chemical Properties

Molecular Weight	623.68
Formula	C₂₇H₄₀F₃N₃O₈S
Smiles	O=C(O)[C@H](CC1=CC=CC=C1)NC([C@H](CC(C)C)NC([C@H](CCSC)NC(OC(C)(C)C)=O)=O)=O.OC(C(F)(F)F)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (240.51 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6034 mL	8.0169 mL	16.0339 mL	80.1693 mL
5 mM	0.3207 mL	1.6034 mL	3.2068 mL	16.0339 mL
10 mM	0.1603 mL	0.8017 mL	1.6034 mL	8.0169 mL
20 mM	0.0802 mL	0.4008 mL	0.8017 mL	4.0085 mL
50 mM	0.0321 mL	0.1603 mL	0.3207 mL	1.6034 mL
100 mM	0.0160 mL	0.0802 mL	0.1603 mL	0.8017 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

FPR/FPRL1BocMLF TFA (67247125 free base)Boc-Met-Leu-Phe-OHBoc MLF TFA (67247 12 5 free base)67247-12-5 free base67247-12-5

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