Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sirt1/2-IN-4 (compound PS3) is a potent triple inhibitor of SIRT1, SIRT2, and SIRT3, exhibiting IC50 values of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (SIRT3), respectively. It effectively inhibits p53 deacetylation, indicating potential anticancer properties [1].
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Description | Sirt1/2-IN-4 (compound PS3) is a potent triple inhibitor of SIRT1, SIRT2, and SIRT3, exhibiting IC50 values of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (SIRT3), respectively. It effectively inhibits p53 deacetylation, indicating potential anticancer properties [1]. |
In vitro | Sirt1/2-IN-4 (compound PS3) (5 μM; 48 h) induces apoptosis in various tumor cells, with IC50 values of 6.5 μM (MV4-11), 9.2 μM (MOLM-13), 27.2 μM (THP1), and 17.4 μM (Jurkat) [1]. |
Molecular Weight | 440.54 |
Formula | C21H20N4O3S2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Sirt1/2-IN-4 Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin inhibitor inhibit