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Tetrahexyldecyl ascorbate

Name: Tetrahexyldecyl ascorbate
Brand: TargetMol
SKU: T20174
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20174Cas No. 183476-82-6

Alias Nikkol VC-IP, IPAA, BV-OSC, Ascorbyl tetra-2-hexyldecanoat

Tetrahexyldecyl ascorbate (BV-OSC) is a lipophilic precursor of ascorbic acid, a more stable and permeable form of vitamin C. It is a potent anti-photo-aging and anti-hyperpigmentation antioxidant that inhibits MMP enzyme activity.

Tetrahexyldecyl ascorbate

😃Good

Catalog No. T20174Alias Nikkol VC-IP, IPAA, BV-OSC, Ascorbyl tetra-2-hexyldecanoatCas No. 183476-82-6

Pack Size	Price	USA Warehouse	Global Warehouse
2 g	$31	-	In Stock
5 g	$62	7-10 days	7-10 days
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Tetrahexyldecyl ascorbate (BV-OSC) is a lipophilic precursor of ascorbic acid, a more stable and permeable form of vitamin C. It is a potent anti-photo-aging and anti-hyperpigmentation antioxidant that inhibits MMP enzyme activity.
In vitro	Tetrahexyldecyl ascorbate, either alone or in combination with AZ, was applied to human keratinocytes (HaCaT) and dermal fibroblasts (nHDF, aHDF), and incubated for 0.5 to 3 hours. After treatment, cell viability was assessed using CCK-8, ELISA, and gene chip technologies. The Results showed that Tetrahexyldecyl ascorbate reduced cell viability under oxidative stress, while its combination with AZ significantly enhanced cell activity. The combination therapy upregulated genes related to phospholipid homeostasis and keratinocyte differentiation, inhibited the expression of MMP1 and MMP7, and promoted collagen synthesis in dermal fibroblasts [1].
Synonyms	Nikkol VC-IP, IPAA, BV-OSC, Ascorbyl tetra-2-hexyldecanoat

Chemical Properties

Molecular Weight	1129.76
Formula	C₇₀H₁₂₈O₁₀
Cas No.	183476-82-6
Smiles	[C@H](OC(C(CCCCCCCC)CCCCCC)=O)(COC(C(CCCCCCCC)CCCCCC)=O)[C@@]1(C(OC(C(CCCCCCCC)CCCCCC)=O)=C(OC(C(CCCCCCCC)CCCCCC)=O)C(=O)O1)[H]
Relative Density.	0.928-0.941 g/cm3 at 20℃
Color	Transparent
Appearance	Liquid

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 180 mg/mL (159.33 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (4.43 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8851 mL	4.4257 mL	8.8514 mL	44.2572 mL
5 mM	0.1770 mL	0.8851 mL	1.7703 mL	8.8514 mL
10 mM	0.0885 mL	0.4426 mL	0.8851 mL	4.4257 mL
20 mM	0.0443 mL	0.2213 mL	0.4426 mL	2.2129 mL
50 mM	0.0177 mL	0.0885 mL	0.1770 mL	0.8851 mL
100 mM	0.0089 mL	0.0443 mL	0.0885 mL	0.4426 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc