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Tetrahexyldecyl ascorbate

Name: Tetrahexyldecyl ascorbate
Brand: TargetMol
SKU: T20174
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20174Cas No. 183476-82-6

Alias Nikkol VC-IP, IPAA, BV-OSC, Ascorbyl tetra-2-hexyldecanoat

Tetrahexyldecyl ascorbate (BV-OSC) is a lipophilic precursor of ascorbic acid, a more stable and permeable form of vitamin C. It is a potent anti-photo-aging and anti-hyperpigmentation antioxidant that inhibits MMP enzyme activity.

Tetrahexyldecyl ascorbate

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Catalog No. T20174Alias Nikkol VC-IP, IPAA, BV-OSC, Ascorbyl tetra-2-hexyldecanoatCas No. 183476-82-6

Pack Size	Price	USA Warehouse	Global Warehouse
2 g	$31	-	In Stock
5 g	$62	7-10 days	7-10 days
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Liquid

Color:Transparent

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COA HNMR MS

Product Introduction

Bioactivity

Description	Tetrahexyldecyl ascorbate (BV-OSC) is a lipophilic precursor of ascorbic acid, a more stable and permeable form of vitamin C. It is a potent anti-photo-aging and anti-hyperpigmentation antioxidant that inhibits MMP enzyme activity.
In vitro	Tetrahexyldecyl ascorbate, either alone or in combination with AZ, was applied to human keratinocytes (HaCaT) and dermal fibroblasts (nHDF, aHDF), and incubated for 0.5 to 3 hours. After treatment, cell viability was assessed using CCK-8, ELISA, and gene chip technologies. The Results showed that Tetrahexyldecyl ascorbate reduced cell viability under oxidative stress, while its combination with AZ significantly enhanced cell activity. The combination therapy upregulated genes related to phospholipid homeostasis and keratinocyte differentiation, inhibited the expression of MMP1 and MMP7, and promoted collagen synthesis in dermal fibroblasts [1].
Synonyms	Nikkol VC-IP, IPAA, BV-OSC, Ascorbyl tetra-2-hexyldecanoat

Chemical Properties

Molecular Weight	1129.76
Formula	C₇₀H₁₂₈O₁₀
Cas No.	183476-82-6
Smiles	[C@H](OC(C(CCCCCCCC)CCCCCC)=O)(COC(C(CCCCCCCC)CCCCCC)=O)[C@@]1(C(OC(C(CCCCCCCC)CCCCCC)=O)=C(OC(C(CCCCCCCC)CCCCCC)=O)C(=O)O1)[H]
Relative Density.	0.928-0.941 g/cm3 at 20℃

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 180 mg/mL (159.33 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (4.43 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8851 mL	4.4257 mL	8.8514 mL	44.2572 mL
5 mM	0.1770 mL	0.8851 mL	1.7703 mL	8.8514 mL
10 mM	0.0885 mL	0.4426 mL	0.8851 mL	4.4257 mL
20 mM	0.0443 mL	0.2213 mL	0.4426 mL	2.2129 mL
50 mM	0.0177 mL	0.0885 mL	0.1770 mL	0.8851 mL
100 mM	0.0089 mL	0.0443 mL	0.0885 mL	0.4426 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc