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Semaglutide Acetate

Catalog No. T19850L CAS 1997361-85-9

Synonyms: Semaglutide Acetate(910463-68-2 Free base)

Semaglutide Acetate is an agonist of a glucagon-like peptide 1 (GLP-1) receptor and can be used in studies about the treatment of type 2 diabetes.

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Semaglutide Acetate, CAS 1997361-85-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 239.00
5 mg	In stock	$ 498.00
10 mg	In stock	$ 725.00
25 mg	In stock	$ 1,130.00
50 mg	In stock	$ 1,520.00

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Purity: 98.42%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Semaglutide Acetate is an agonist of a glucagon-like peptide 1 (GLP-1) receptor and can be used in studies about the treatment of type 2 diabetes.
In vitro	Semaglutide Acetate is a long-acting GLP-1 analogue with GLP-1 receptor affinity of 0.38 nM[3].
In vivo	Semaglutide Acetate improves 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-induced motor impairments. Semaglutide Acetate rescues the decrease of tyrosine hydroxylase (TH) levels, reduces lipid peroxidation, inhibits the apoptosis pathway, alleviates the inflammation response, increases autophagy-related protein expression, and protects dopaminergic neurons in the substantia nigra and striatum[2]. In mini-pigs, The plasma half-life of Semaglutide Acetate (i.v.) is 46h and the MRT of Semaglutide Acetate (s.c.) is 63.6h[3].

Synonyms	Semaglutide Acetate(910463-68-2 Free base)
Molecular Weight	4174.68
Formula	C189H295N45O61
CAS No.	1997361-85-9

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: <0.05 mg/mL (insoluble)

DMSO: 4.17 mg/mL (1 mM), Sonication and heating are recommended.

References and Literature

1. Zhang L, et al. Neuroprotective effects of the novel GLP-1 long acting analogue semaglutide in the MPTP Parkinson's disease mouse model. Neuropeptides. 2018 Oct;71:70-80. 2. Dhillon S, et al. Semaglutide: First Global Approval. Drugs. 2018 Feb;78(2):275-284. 3. Marso SP, et al. Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. N Engl J Med. 2016 Nov 10;375(19):1834-1844.

Related compound libraries

This product is contained In the following compound libraries：

Peptide Compound Library

Related Products

Related compounds with same targets

3-Deoxyglucosone Tirzepatide Acetate(2023788-19-2 free base) GLP-1R Agonist DMB Lixisenatide acetate (320367-13-3 free base) Shanzhiside methyl ester Orforglipron GLP-1 receptor agonist 9 Retatrutide sodium salt

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Semaglutide Acetate 1997361-85-9 GPCR/G Protein Glucagon Receptor Semaglutide Acetate(910463-68-2 Free base) inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.