Anti-Mouse CD11b Antibody (M1/70) is a rat-derived antibody targeting mouse CD11b that can significantly inhibit the adhesion between dendritic cells (DCs) and platelets, kill ovarian cancer cells and suppress their migration, as well as alleviate renal fibrosis and inflammation. This antibody can be used in the research of inflammatory diseases and cancers, such as ischemia-reperfusion injury (IRI), thrombotic inflammatory diseases and ovarian cancer .

Anti-Mouse CD11b Antibody (M1/70) (10 μg/mL, 30 minutes) significantly inhibited the adhesion of bone marrow-derived dendritic cells (bmDCs) to immobilized platelets [2]; this antibody (5–10 μg/mL, 24 hours) markedly killed epithelial ovarian cancer (EOC) cells [3]; at 5–15 μg/mL for 36 hours, it dose-dependently suppressed the migration of SKOV-3 and MDAH-2774 cells [3].

Anti-Mouse CD11b Antibody (M1/70) (2.5 mg/kg, intraperitoneal injection, once every 2 days for 14 days) significantly reduced renal fibrosis and inflammation in male C57BL/6J mice with ischemia-reperfusion injury (IRI) [1].
Anti-Mouse CD11b Antibody (M1/70) (50 μg, intravenous injection, single dose) significantly inhibited the adhesion of DC cells to injured blood vessels in wild-type C57BL/6 mice in the carotid artery ligation model [2].
Anti-Mouse CD11b Antibody (M1/70) (60 μg, intratumoral injection, once daily for 5 consecutive days) significantly inhibited tumor growth in female Nude-Oxn1nu mice bearing SKOV-3 tumors [3].

M1/70

Mouse/Human

Monoclonal

Unconjugated