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IL-10R beta/IL-10RB Protein, Human, Recombinant (hFc)

Catalog No. TMPJ-00213
Synonyms: Cytokine receptor family 2 member 4, Interleukin-10 receptor subunit 2, Interleukin-10 receptor subunit beta(IL10RB), Cytokine receptor class-II member 4, Interleukin-10 receptor subunit β(IL10RB)

Interleukin-10 receptor subunit beta(IL10RB), also known as Cytokine receptor class-II member 4,Cytokine receptor family 2 member 4,Interleukin-10 receptor subunit 2, belongs to the type II cytokine receptor family. IL10RB is a single- pass type I membrane protein and contains two fibronectin type-III domains. It is an accessory chain which is essential for the active interleukin 10 receptor complex. Coexpression of IL10RB and IL10RA proteins has been shown to be required for IL10-induced signal transduction. Defects in IL10RB are the cause of inflammatory bowel disease type 25 (IBD25) which is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology.

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IL-10R beta/IL-10RB Protein, Human, Recombinant (hFc)
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 60.00
50 μg 5 days $ 184.00
500 μg 5 days $ 806.00
1 mg 5 days $ 1,060.00
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Biological Description
Technical Params
Product Properties
Description Interleukin-10 receptor subunit beta(IL10RB), also known as Cytokine receptor class-II member 4,Cytokine receptor family 2 member 4,Interleukin-10 receptor subunit 2, belongs to the type II cytokine receptor family. IL10RB is a single- pass type I membrane protein and contains two fibronectin type-III domains. It is an accessory chain which is essential for the active interleukin 10 receptor complex. Coexpression of IL10RB and IL10RA proteins has been shown to be required for IL10-induced signal transduction. Defects in IL10RB are the cause of inflammatory bowel disease type 25 (IBD25) which is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology.
Species Human
Expression System Human Cells
Tag C-Fc
Accession Number Q08334
Synonyms Cytokine receptor family 2 member 4, Interleukin-10 receptor subunit 2, Interleukin-10 receptor subunit beta(IL10RB), Cytokine receptor class-II member 4, Interleukin-10 receptor subunit β(IL10RB)
Amino Acid Met20-Ser220
Construction Recombinant Human Interleukin-10 Receptor Subunit Beta is produced by our Mammalian expression system and the target gene encoding Met20-Ser220 is expressed with a human IgG1 Fc tag at the C-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 75-95 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.

Research Background Interleukin-10 receptor subunit beta(IL10RB), also known as Cytokine receptor class-II member 4,Cytokine receptor family 2 member 4,Interleukin-10 receptor subunit 2, belongs to the type II cytokine receptor family. IL10RB is a single- pass type I membrane protein and contains two fibronectin type-III domains. It is an accessory chain which is essential for the active interleukin 10 receptor complex. Coexpression of IL10RB and IL10RA proteins has been shown to be required for IL10-induced signal transduction. Defects in IL10RB are the cause of inflammatory bowel disease type 25 (IBD25) which is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology.

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Keywords

IL-10R beta/IL-10RB Protein, Human, Recombinant (hFc) Cytokine receptor family 2 member 4 Interleukin-10 receptor subunit 2 Interleukin-10 receptor subunit beta(IL10RB) Cytokine receptor class-II member 4 Interleukin-10 receptor subunit β(IL10RB) recombinant recombinant-proteins proteins protein

 

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