NCR1 Protein, Mouse, Recombinant (hFc)

Natural cytotoxicity triggering receptor 1(NKp46/NCR1) is a single-pass type I membrane protein. It consists of two extracellular Ig-like domains followed by a short stalk region, a transmembrane domain containing a positively charged amino acid residue, and a short cytoplasmictail. NKp46 is predominantly expressed in the embryo. It has a positive charge in its transmembrane domain that permits association with the ITAM-bearing signal adapter proteins, CD3 zeta and Fc epsilon RI gamma. These receptors are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells. Studies with neutralizing antibodies indicate that the three NCR are primarily responsible for triggering the NK-mediated lysis of many human tumor celllines.

Pack Size	Availability	Price/USD
10 μg	5 days	$ 110.00
50 μg	5 days	$ 310.00
500 μg	5 days	$ 1,390.00
1 mg	5 days	$ 1,980.00

Pack Size

Availability

Price/USD

Quantity

10 μg

5 days

$ 110.00

50 μg

5 days

$ 310.00

500 μg

5 days

$ 1,390.00

1 mg

5 days

$ 1,980.00

Description

Species	Mouse
Expression System	Human Cells
Tag	C-Fc
Accession Number	Q8C567
Synonyms	NKp46, mNKp46, NK-p46, Lymphocyte antigen94, Activating receptor1, Naturalkiller cell p46-related protein
Amino Acid	Glu22-Asn255
Construction	Recombinant Mouse Natural Cytotoxicity Triggering Receptor 1 is produced by our Mammalian expression system and the target gene encoding Glu22-Asn255 is expressed with a human IgG1 Fc tag at the C-terminus.
Protein Purity	Greater than 90% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight	76 KDa, reducing conditions

Endotoxin	Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution	Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Stability & Storage	Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Research Background	Natural cytotoxicity triggering receptor 1(NKp46/NCR1) is a single-pass type I membrane protein. It consists of two extracellular Ig-like domains followed by a short stalk region, a transmembrane domain containing a positively charged amino acid residue, and a short cytoplasmictail. NKp46 is predominantly expressed in the embryo. It has a positive charge in its transmembrane domain that permits association with the ITAM-bearing signal adapter proteins, CD3 zeta and Fc epsilon RI gamma. These receptors are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells. Studies with neutralizing antibodies indicate that the three NCR are primarily responsible for triggering the NK-mediated lysis of many human tumor celllines.

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NCR1 Protein, Mouse, Recombinant (hFc)

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