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Maxacalcitol

Name: Maxacalcitol
Brand: TargetMol
SKU: T16015
Rating: 4.5 (1 reviews)

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Catalog No. T16015Cas No. 103909-75-7

Alias 22-Oxacalcitriol

Maxacalcitol (22-Oxacalcitriol) is a ligand of VDR-like receptors and a non-serum calcium vitamin D3 analogue. Maxacalcitol inhibits parathyroid hormone (PTH) mRNA expression in vitro and in vivo.

Maxacalcitol

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Catalog No. T16015Alias 22-OxacalcitriolCas No. 103909-75-7

Maxacalcitol (22-Oxacalcitriol) is a ligand of VDR-like receptors and a non-serum calcium vitamin D3 analogue. Maxacalcitol inhibits parathyroid hormone (PTH) mRNA expression in vitro and in vivo.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$118	4-6 weeks	4-6 weeks
5 mg	Inquiry	4-6 weeks	4-6 weeks
10 mg	Inquiry	4-6 weeks	4-6 weeks
25 mg	Inquiry	4-6 weeks	4-6 weeks
50 mg	Inquiry	4-6 weeks	4-6 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Maxacalcitol (22-Oxacalcitriol) is a ligand of VDR-like receptors and a non-serum calcium vitamin D3 analogue. Maxacalcitol inhibits parathyroid hormone (PTH) mRNA expression in vitro and in vivo.
In vitro	Maxacalcitol inhibits parathyroid hormone (PTH) mRNA expression in vitro and in vivo. Maxacalcitol inhibits tumor growth of osteosarcoma in vitro in combination with all-trans retinoic acid. Maxacalcitol shows similar effects to calcitriol in osteoblast-like cells.
Synonyms	22-Oxacalcitriol

Chemical Properties

Molecular Weight	418.61
Formula	C₂₆H₄₂O₄
Cas No.	103909-75-7
Smiles	CC[C@H]1CC[C@H]2C(CCC[C@]12C)=CC=C1C[C@@H](O)C[C@H](O)C1=C
Relative Density.	1.09 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (238.89 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.88 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3889 mL	11.9443 mL	23.8886 mL	119.4429 mL
5 mM	0.4778 mL	2.3889 mL	4.7777 mL	23.8886 mL
10 mM	0.2389 mL	1.1944 mL	2.3889 mL	11.9443 mL
20 mM	0.1194 mL	0.5972 mL	1.1944 mL	5.9721 mL
50 mM	0.0478 mL	0.2389 mL	0.4778 mL	2.3889 mL
100 mM	0.0239 mL	0.1194 mL	0.2389 mL	1.1944 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc