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VP3.15 dihydrobromide

Name: VP3.15 dihydrobromide
Brand: TargetMol
SKU: T5956
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T5956Cas No. 1281681-33-1

VP3.15 dihydrobromide is a potent, orally bioavailable, and CNS-penetrant dual inhibitor of phosphodiesterase (PDE7) and glycogen synthase kinase (GSK)3, with IC50 values of 1.59 μM and 0.88 μM, respectively.

VP3.15 dihydrobromide

🥰Excellent

Purity: 99.67%

Catalog No. T5956Cas No. 1281681-33-1

Pack Size	Price	Availability
5 mg	$38	In Stock
10 mg	$58	In Stock
25 mg	$137	In Stock
50 mg	$238	In Stock
100 mg	$353	In Stock
200 mg	$493	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock

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Batch Information

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Purity:99.67%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	VP3.15 dihydrobromide is a potent, orally bioavailable, and CNS-penetrant dual inhibitor of phosphodiesterase (PDE7) and glycogen synthase kinase (GSK)3, with IC50 values of 1.59 μM and 0.88 μM, respectively.
Targets&IC50	GSK-3:0.88 μM, PDE7:1.59 μM

Chemical Properties

Molecular Weight	528.3
Formula	C₂₀H₂₄Br₂N₄OS
Cas No.	1281681-33-1
Smiles	Br.Br.C(CN1CCOCC1)\N=c1\nc(-c2ccccc2)n(s1)-c1ccccc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 22.5 mg/mL (42.59 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8929 mL	9.4643 mL	18.9286 mL	94.6432 mL
5 mM	0.3786 mL	1.8929 mL	3.7857 mL	18.9286 mL
10 mM	0.1893 mL	0.9464 mL	1.8929 mL	9.4643 mL
20 mM	0.0946 mL	0.4732 mL	0.9464 mL	4.7322 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc