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Anti-CHI3L2 Antibody (6O318)
😃Good
Catalog No. TMAY-02257
Alias YKL-39, YKL39, chitinase 3 like 2, CHIL2
Anti-CHI3L2 Antibody (6O318) is a Rabbit antibody targeting CHI3L2. Anti-CHI3L2 Antibody (6O318) can be used in ELISA,IHC-P.
Anti-CHI3L2 Antibody (6O318)
Anti-CHI3L2 Antibody (6O318)
😃Good
Catalog No. TMAY-02257Alias YKL-39, YKL39, chitinase 3 like 2, CHIL2
Anti-CHI3L2 Antibody (6O318) is a Rabbit antibody targeting CHI3L2. Anti-CHI3L2 Antibody (6O318) can be used in ELISA,IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: ELISA, IHC-P Reactivity: Human |
| Alias | YKL-39, YKL39, chitinase 3 like 2, CHIL2 |
| Ig Type | Rabbit IgG |
| Clone | 6O318 |
| Reactivity | Human |
| Verified Activity | 1. Immunochemical staining of human CHI3L2 in human lung with rabbit monoclonal antibody (1:100, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human CHI3L2 in human hepatoma with rabbit monoclonal antibody (1:100, formalin-fixed paraffin embedded sections). 3. Immunochemical staining of human CHI3L2 in human brain with rabbit monoclonal antibody (1:100, formalin-fixed paraffin embedded sections). |
| Application | ELISA,IHC-P |
| Recommended Dose | ELISA: 1:5000-1:10000; IHC-P: 1:50-1:200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human YKL-39 / CHI3L2 (rh YKL-39 / CHI3L2; TMPY-01933; NP_003991.2; Met1-Leu390). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Chondrocyte protein 39 (YKL-39), also known as Chitinase 3-like 2 (CHI3L2), is a secretory protein of articular chondrocytes belonging to the glycosyl hydrolase 18 family. Its highest expression is in chondrocytes, followed by synoviocytes, lung and heart. YKL-39/CHI3L2 is not detected in spleen, pancreas, and liver. YKL-39/CHI3L2 may also be expressed in developing brain and placenta. YKL-39/CHI3L2, a cartilage-related protein, is found to induce arthritis accompanied by pathologic changes in bone and cartilage. A better understanding of the immune response against cartilage-related components including YKL-39 may help to elucidate the pathological processes of arthritic disorders. Upregulation of YKL-39/CHI3L2 in osteoarthritic cartilage suggests that YKL-39/CHI3L2 may be a more accurate marker of chondrocyte activation than YKL-40, although it has yet to be established as a suitable marker in synovial fluid and serum. The decreased expression of YKL-40 by osteoarthritic chondrocytes is surprising as increased levels have been reported in rheumatoid and osteoarthritic synovial fluid, where it may derive from activated synovial cells or osteophytic tissue or by increased matrix destruction in the osteoarthritic joint. YKL-39 and YKL-40 are potentially interesting marker molecules for arthritic joint disease because they are abundantly expressed by both normal and osteoarthritic chondrocytes. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human YKL-39 / CHI3L2 protein (TMPY-01933) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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