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ZD7288

ZD7288
ZD7288 (ICI D7288), a selective hyperpolarization-activated cyclic nucleotide-gated channel blocker, inhibits hippocampal synaptic plasticity.
Catalog No. T7516Cas No. 133059-99-1
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Purity:99.99%
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ZD7288

Catalog No. T7516Cas No. 133059-99-1

ZD7288 (ICI D7288), a selective hyperpolarization-activated cyclic nucleotide-gated channel blocker, inhibits hippocampal synaptic plasticity.
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Pack SizePriceAvailabilityQuantity
2 mg$30In Stock
5 mg$48In Stock
10 mg$84In Stock
25 mg$192In Stock
50 mg$360In Stock
100 mg$535In Stock
1 mL x 10 mM (in DMSO)$48In Stock
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Product Introduction

Bioactivity
Description
ZD7288 (ICI D7288), a selective hyperpolarization-activated cyclic nucleotide-gated channel blocker, inhibits hippocampal synaptic plasticity.
In vitro
ZD7288 attenuated glutamate-induced rises in [Ca(2+)]i in a concentration-dependent manner and reversed 8-Br-cAMP-mediated facilitation of these glutamate-induced [Ca(2+)]i rises.?ZD7288 inhibits hippocampal synaptic plasticity both glutamate release and resultant [Ca(2+)]i increases in rat hippocampal neurons[1].
Cell Research
Cultured hippocampal neurons were incubated with 1 μM Fura-2 acetoxy-methylol ester for 30 minutes at 37°C, washed three times with artificial cerebrospinal fluid (containing 140 mM NaCl, 5 mM KCl, 2 mM CaCl2, 1 mM MgCl2, 10 mM glucose and 10 mM hydroxyethyl piperazine ethanesulfonic acid, pH 7.3), and then incubated at room temperature in the dark for 30 minutes.?Fura-2 fluorescence was observed by a Ratio Vision digital fluorescence microscopy system.?Fluorescence signals were evoked by 340 and 380 nm excitation wavelengths and collected at 510 nm by TILLvisION 4.0 software.?The 340:380 nm fluorescence ratio was used to represent [Ca2+]i.?Peak calcium change was represented as the percentage increase from baseline.?Neurons were incubated in ZD7288 (25, 50 or 100 μM) or 8-Br-cAMP (5 or 50 μM) for 15 minutes prior to stimulation with 50 μM glutamate.?All experiments were repeated in triplicate, using different batches of cells across 4–5 dishes[1].
AliasICI D7288
Chemical Properties
Molecular Weight292.81
FormulaC15H21ClN4
Cas No.133059-99-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 50 mg/mL (170.76 mM)
DMSO: 50 mg/mL (170.76 mM)
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM3.4152 mL17.0759 mL34.1518 mL170.7592 mL
5 mM0.6830 mL3.4152 mL6.8304 mL34.1518 mL
10 mM0.3415 mL1.7076 mL3.4152 mL17.0759 mL
20 mM0.1708 mL0.8538 mL1.7076 mL8.5380 mL
50 mM0.0683 mL0.3415 mL0.6830 mL3.4152 mL
100 mM0.0342 mL0.1708 mL0.3415 mL1.7076 mL

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