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ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His)

Catalog No. TMPJ-00850
Synonyms: Protein T1, suppression of tumorigenicity 2, Ly84, DER4, Fit-1, Lymphocyte antigen 84, Interleukin-1 receptor-like 1, IL-1 R4, ST2V, ST2L, IL-33R, Protein ST2, Il1rl1, IL-1RL1

ST2, also called IL-1 R4, is an Interleukin-1 receptor family glycoprotein that plays a role in Th2 immune responses. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiac myocytes. This receptor is very similar to the IL-1 receptor type I and the IL-18 receptor α chain in that ST2 also has three extracellular Ig domains and an intracellular Toll domain. ST2 binds IL-33, enhances inflammatory cytokines by activating nuclear factor-κB (NF-κB) and mitogen activated protein (MAP) kinases. ST2 exists as either a membrane bound form (ST2L) or as a soluble form (sST2). ST2L acts as a transmembrane signalling receptor for IL-33 by mediating the effect of IL-33 on the inflammatory process, while sST2 can suppress IL-33 activity.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His)
Pack Size Availability Price/USD Quantity
10 μg In stock $ 75.00
50 μg 5 days $ 197.00
500 μg 5 days $ 1,220.00
1 mg 5 days $ 2,730.00
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Biological Description
Technical Params
Product Properties
Biological Information Immobilized Mouse ST2-His at 5μg/ml (100 μl/well) can bind Rhesus Macaque IL-33-His. The ED50 of Rhesus Macaque IL-33-His is 82.03 ng/ml. (Regularly tested)

Description ST2, also called IL-1 R4, is an Interleukin-1 receptor family glycoprotein that plays a role in Th2 immune responses. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiac myocytes. This receptor is very similar to the IL-1 receptor type I and the IL-18 receptor α chain in that ST2 also has three extracellular Ig domains and an intracellular Toll domain. ST2 binds IL-33, enhances inflammatory cytokines by activating nuclear factor-κB (NF-κB) and mitogen activated protein (MAP) kinases. ST2 exists as either a membrane bound form (ST2L) or as a soluble form (sST2). ST2L acts as a transmembrane signalling receptor for IL-33 by mediating the effect of IL-33 on the inflammatory process, while sST2 can suppress IL-33 activity.
Species Mouse
Expression System Human Cells
Tag C-6His
Accession Number P14719-2
Synonyms Protein T1, suppression of tumorigenicity 2, Ly84, DER4, Fit-1, Lymphocyte antigen 84, Interleukin-1 receptor-like 1, IL-1 R4, ST2V, ST2L, IL-33R, Protein ST2, Il1rl1, IL-1RL1
Amino Acid Ser27-Ala337
Construction Recombinant Mouse Interleukin-1 Receptor-like 1 is produced by our Mammalian expression system and the target gene encoding Ser27-Ala337 is expressed with a 6His tag at the C-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)

Molecular Weight 55-70 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Research Background ST2, also called IL-1 R4, is an Interleukin-1 receptor family glycoprotein that plays a role in Th2 immune responses. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiac myocytes. This receptor is very similar to the IL-1 receptor type I and the IL-18 receptor α chain in that ST2 also has three extracellular Ig domains and an intracellular Toll domain. ST2 binds IL-33, enhances inflammatory cytokines by activating nuclear factor-κB (NF-κB) and mitogen activated protein (MAP) kinases. ST2 exists as either a membrane bound form (ST2L) or as a soluble form (sST2). ST2L acts as a transmembrane signalling receptor for IL-33 by mediating the effect of IL-33 on the inflammatory process, while sST2 can suppress IL-33 activity.

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Keywords

ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His) Protein T1 suppression of tumorigenicity 2 Ly84 DER4 Fit-1 Lymphocyte antigen 84 Interleukin-1 receptor-like 1 IL-1 R4 ST2V ST2L IL-33R Protein ST2 Il1rl1 DER-4 IL-1RL1 DER 4 recombinant recombinant-proteins proteins protein

 

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