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3-Methoxycatechol

Name: 3-Methoxycatechol
Brand: TargetMol
SKU: T77555
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T77555Cas No. 934-00-9

Alias 1,2-Dihydroxy-3-methoxybenzene

3-Methoxycatechol is a lignin-derived renewable chemical that promotes carcinogenesis in the esophagus.1,2-Dihydroxy-3-methoxybenzen exhibits strong antiviral activity against encephalomyelitis virus (EMCV).

3-Methoxycatechol

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Purity: 99.73%

Catalog No. T77555Alias 1,2-Dihydroxy-3-methoxybenzeneCas No. 934-00-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.73%

Appearance:Oil

Color:White

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COA HPLC HNMR

Product Introduction

3-Methoxycatechol AI Summary

3-Methoxycatechol has been tested in diverse bioassays, indicating significant multifunctional bioactivities. It shows potency in modulating Lamin A splicing, inhibiting HSD17B4 and JMJD2E, and preventing Tau fibril formation. Additionally, it inhibits several enzymes including ALDH1A1, cytochrome P450, lipoxygenase, fructose-1,6-bisphosphate aldolase, ERK signaling, HPGD, lipoxygenase-2, the vitamin D receptor, Polymerase Kappa, tyrosyl-DNA phosphodiesterase 1, and APE1. It targets cancer cells with p53 mutations, suppresses ROR gamma transcriptional activity, and inhibits viral entry for Lassa and Marburg viruses, along with targeting the foot and mouth disease virus. Interestingly, it both activates and inhibits Cytochrome P450 3A4. Moreover, 3-Methoxycatechol inhibits the uptake of sodium fluorescein significantly in OATP1B1 and OATP1B3 transfected CHO cells at 10 uM, with inhibition percentages of 98.75% and 107.5%, respectively, indicating potential bioactivities in OATP1B1 and OATP1B3 transporter inhibition. In cytotoxicity assays, 3-Methoxycatechol exhibits growth inhibition in human TK10, UACC62, and MCF7 cells with GI50 values between 23,640 nM to 51,630 nM, TGI values from 50,260 nM to 96,980 nM, and LC50 values ranging from 76,870 nM to above 100,000 nM. These results suggest its antiproliferative and cytotoxic potential across various human cell lines..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	3-Methoxycatechol is a lignin-derived renewable chemical that promotes carcinogenesis in the esophagus.1,2-Dihydroxy-3-methoxybenzen exhibits strong antiviral activity against encephalomyelitis virus (EMCV).
Synonyms	1,2-Dihydroxy-3-methoxybenzene

Chemical Properties

Molecular Weight	140.14
Formula	C₇H₈O₃
Cas No.	934-00-9
Smiles	COc1cccc(O)c1O

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (356.79 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (35.68 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.1357 mL	35.6786 mL	71.3572 mL	356.7861 mL
5 mM	1.4271 mL	7.1357 mL	14.2714 mL	71.3572 mL
10 mM	0.7136 mL	3.5679 mL	7.1357 mL	35.6786 mL
20 mM	0.3568 mL	1.7839 mL	3.5679 mL	17.8393 mL
50 mM	0.1427 mL	0.7136 mL	1.4271 mL	7.1357 mL
100 mM	0.0714 mL	0.3568 mL	0.7136 mL	3.5679 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc