Anti-Mouse PD-1 Antibody (J43)

Anti-Mouse PD-1 Antibody (J43) is an inhibitory antibody derived from Armenian hamsters, with its target being mouse PD-1. This antibody can effectively block the interaction between PD-1 and PD-L1, and is widely used in cancer and immunology-related research, including research directions such as breast cancer and colon cancer.

Anti-Mouse PD-1 Antibody (J43) administered intratumorally at a dose of 10 μg (once each on day 0 and day 3) can effectively inhibit tumor growth and prolong the survival period of mice in the MCA tumor model[1].
In the B16F10 or Colon 26 tumor mouse model, the combined use of Anti-Mouse PD-1 Antibody (J43) (200 μg, intraperitoneally injected on days 4, 8, 14, and 18) and anti-CD4 antibody can achieve tumor growth inhibition[2].

When Anti-Mouse PD-1 Antibody (J43) is administered by intraperitoneal injection (500 μg/mouse on day 14, and 250 μg/mouse every other day from day 16 to day 32), it induces fatal hypersensitivity in the inflammatory 4T1 breast cancer model[3].

In the ID8 tumor-bearing mouse model, the combined administration of Anti-Mouse PD-1 Antibody (J43) (200 μg, intraperitoneally injected twice a week for 2 weeks) with R428 or SGI-7079 can significantly improve the survival rate of mice[4].

J43

Mouse

Immobilized Mouse PD-1 Protein (hFc) (TMPY-05395) at 8 μg/mL (100 μL/well) can bind Anti-Mouse PD-1 Antibody (J43). The EC50 is 776.30 ng/mL.

Monoclonal

Unconjugated