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RAF709

Name: RAF709
Brand: TargetMol
SKU: T3711
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3711Cas No. 1628838-42-5

RAF709 is a novel Raf kinase inhibitor with IC50s of 0.5 and 1.8 nM for c-Raf and b-Raf, respectively.

RAF709

🥰Excellent

Purity: 99.8%

Catalog No. T3711Cas No. 1628838-42-5

RAF709 is a novel Raf kinase inhibitor with IC50s of 0.5 and 1.8 nM for c-Raf and b-Raf, respectively.

Pack Size	Price	Availability
1 mg	$34	In Stock
2 mg	$48	In Stock
5 mg	$79	In Stock
10 mg	$133	In Stock
25 mg	$272	In Stock
50 mg	$446	In Stock
100 mg	$658	In Stock
500 mg	$1,380	In Stock
1 mL x 10 mM (in DMSO)	$95	In Stock

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Purity:99.8%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	RAF709 is a novel Raf kinase inhibitor with IC50s of 0.5 and 1.8 nM for c-Raf and b-Raf, respectively.
Targets&IC50	B-Raf:1.8 nM, C-Raf:0.5 nM
In vitro	The invention provides compounds (e.g., RAF709) that inhibit Raf kinases, and are accordingly useful for treating certain disorders associated with excessive Raf kinase activity, including cell proliferation disorders such as cancers[1].

Chemical Properties

Molecular Weight	542.55
Formula	C₂₈H₂₉F₃N₄O₄
Cas No.	1628838-42-5
Smiles	Cc1ncc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cnc(OC2CCOCC2)c(c1)N1CCOCC1
Relative Density.	1.321 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 91 mg/mL (167.73 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.08 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8431 mL	9.2157 mL	18.4315 mL	92.1574 mL
5 mM	0.3686 mL	1.8431 mL	3.6863 mL	18.4315 mL
10 mM	0.1843 mL	0.9216 mL	1.8431 mL	9.2157 mL
20 mM	0.0922 mL	0.4608 mL	0.9216 mL	4.6079 mL
50 mM	0.0369 mL	0.1843 mL	0.3686 mL	1.8431 mL
100 mM	0.0184 mL	0.0922 mL	0.1843 mL	0.9216 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc