Shopping Cart
Remove All
Your shopping cart is currently empty
Anti-AXL Antibody (2V194)
(Synonyms: UFO, Tyro7, JTK11, EC 2.7.10.1, EC 2.7.10, AXL oncogene, Axl, ARK, AI323647) Copy Product Info
🥰Excellent
Synonyms: UFO, Tyro7, JTK11, EC 2.7.10.1, EC 2.7.10, AXL oncogene, Axl, ARK, AI323647
Catalog No. TMAH-00099 Copy Product Info
🥰Excellent
Anti-AXL Antibody (2V194) is an antibody targeting AXL. Anti-AXL Antibody (2V194) can be used in ELISA.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $209 | 7-10 days | 7-10 days | |
| 100 μL | $347 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
Add to Cart
Add to Quotation
For research use only—not for human use. No sales to individuals. Use as intended only.
Resource Download
Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-AXL Antibody (2V194) is an antibody targeting AXL. Anti-AXL Antibody (2V194) can be used in ELISA. |
| Synonyms | UFO, Tyro7, JTK11, EC 2.7.10.1, EC 2.7.10, AXL oncogene, Axl, ARK, AI323647 |
| Ig Type | hIgG1 |
| Clone | 2V194 |
| Reactivity | Human |
| Application | |
| Recommended Dose | ELISA:1:5000-1:50000. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cell membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| Research Background | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. (Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human AXL Protein |
| Antigen Species | Human |
| Gene Name | AXL |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Cancer, Cell biology, Tags & Cell Markers, Signal transduction |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
Calculator
Preview
Related Tags: Anti-AXL Antibody (2V194) chemical structure
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.