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TPST2-IN-1
Catalog No. T214705 Copy Product Info
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TPST2-IN-1 is a potent and selective TPST2 inhibitor, with an IC50 of 946 nM and a Ka of 19.4 μM. It functions by inhibiting TPST2 activity, thereby increasing the phosphorylation level of Stat1 and upregulating the expression of the IFNγ-responsive gene CXCL10. Exhibiting antitumor activity, TPST2-IN-1 enhances T cell-mediated antitumor immunity, characterized by increased infiltration of effector CD8+ T cells. This compound is applicable in cancer research, such as studies involving colorectal cancer.
TPST2-IN-1
Copy Product Info🥰Excellent
Catalog No. T214705
TPST2-IN-1 is a potent and selective TPST2 inhibitor, with an IC50 of 946 nM and a Ka of 19.4 μM. It functions by inhibiting TPST2 activity, thereby increasing the phosphorylation level of Stat1 and upregulating the expression of the IFNγ-responsive gene CXCL10. Exhibiting antitumor activity, TPST2-IN-1 enhances T cell-mediated antitumor immunity, characterized by increased infiltration of effector CD8+ T cells. This compound is applicable in cancer research, such as studies involving colorectal cancer.
TPST2-IN-1
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | TPST2-IN-1 is a potent and selective TPST2 inhibitor, with an IC50 of 946 nM and a Ka of 19.4 μM. It functions by inhibiting TPST2 activity, thereby increasing the phosphorylation level of Stat1 and upregulating the expression of the IFNγ-responsive gene CXCL10. Exhibiting antitumor activity, TPST2-IN-1 enhances T cell-mediated antitumor immunity, characterized by increased infiltration of effector CD8+ T cells. This compound is applicable in cancer research, such as studies involving colorectal cancer. |
| In vitro | TPST2-IN-1 (Compound 77c) enhances IFNγ-induced Cxcl10 gene expression in MC38 cells and promotes STAT1 phosphorylation at concentrations of 0.5-1 μM over 24-48 hours, while it reduces the tyrosine sulfation level of IFNγ receptor 1 (IFNGR1) in HEK293 cells. Additionally, TPST2-IN-1 at 2 μM for 1 hour increases the thermal stability of TPST2 in MDA-MB-231 cells that overexpress Flag-TPST2. |
| In vivo | TPST2-IN-1 (Compound 77c) (50 mg/kg; intraperitoneal injection; daily; 1 day) inhibits tumor growth and enhances T cell infiltration in a subcutaneous MC38 colon cancer model in C57BL/6 mice. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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