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TNO155

Name: TNO155
Brand: TargetMol
SKU: T13176
Price: 91 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13176Cas No. 1801765-04-7

Alias Batoprotafib

TNO155 is a protein tyrosine phosphatase (PTP) non-receptor type 11 (SHP2; src homology region 2 domain phosphatase; PTPN11) inhibitor(IC50 : 0.011 μM),with potential antineoplastic activity.

TNO155

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Purity: 99.63%

Catalog No. T13176Alias BatoprotafibCas No. 1801765-04-7

TNO155 is a protein tyrosine phosphatase (PTP) non-receptor type 11 (SHP2; src homology region 2 domain phosphatase; PTPN11) inhibitor(IC50 : 0.011 μM),with potential antineoplastic activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$91	In Stock	In Stock
2 mg	$129	In Stock	In Stock
5 mg	$216	In Stock	In Stock
10 mg	$322	In Stock	In Stock
25 mg	$547	In Stock	In Stock
50 mg	$788	In Stock	In Stock
100 mg	$1,080	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$238	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.63%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR HPLC

Product Introduction

TNO155 AI Summary

TNO155 displays a range of bioactivities, including notable allosteric inhibition of the SHP2 enzyme, with an IC50 of 11.0 nM in both 6x-histidine tagged human SHP2 expressed in E. coli and human KYSE-520 cells, where it reduces ERK1/2 phosphorylation. It demonstrates significant antiproliferative activity against various cancer cells, such as human KYSE-520 cells (IC50 = 100.0 nM), and human breast cancer cells MDA-MB-231 and MDA-MB-468, leading to cell cycle arrest and apoptosis particularly in MDA-MB-231 cells during different phases, most notably the S phase. Moreover, it exhibits antitumor activity in a mouse model against EMT6 cells, showing significant tumor growth inhibition. However, the compound also presents toxicity under irradiation in mouse 3T3 cells (IC50 = 666000.0 nM) and varied effects on cell viability across different cell types. In HEK293T and U2OS cells, it alters growth rates variably, enhancing growth consistently in U2OS cells while having mixed stimulating and inhibitory effects on human fibroblasts. Thermal shift assays reveal that TNO155 affects the stability of different protein domains, both decreasing and increasing thermal stability, suggesting potential domain-specific impacts on protein structure and function. Overall, these bioactivities highlight TNO155's potential as an anti-cancer agent with significant enzyme inhibition properties, albeit with consideration of its cell-type-specific effects and toxicity..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	TNO155 is a protein tyrosine phosphatase (PTP) non-receptor type 11 (SHP2; src homology region 2 domain phosphatase; PTPN11) inhibitor(IC50 : 0.011 μM),with potential antineoplastic activity.
Targets&IC50	SHP2:0.011 µM
Synonyms	Batoprotafib

Chemical Properties

Molecular Weight	421.95
Formula	C₁₈H₂₄ClN₇OS
Cas No.	1801765-04-7
Smiles	C[C@@H]1OCC2(CCN(CC2)c2cnc(Sc3ccnc(N)c3Cl)c(N)n2)[C@@H]1N
Relative Density.	1.47 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (118.5 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (5.92 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3699 mL	11.8497 mL	23.6995 mL	118.4975 mL
5 mM	0.4740 mL	2.3699 mL	4.7399 mL	23.6995 mL
10 mM	0.2370 mL	1.1850 mL	2.3699 mL	11.8497 mL
20 mM	0.1185 mL	0.5925 mL	1.1850 mL	5.9249 mL
50 mM	0.0474 mL	0.2370 mL	0.4740 mL	2.3699 mL
100 mM	0.0237 mL	0.1185 mL	0.2370 mL	1.1850 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc